Recent advances in NHC–palladium catalysis for alkyne chemistry: versatile synthesis and applications

Abstract

During the past decades, alkynes chemistry has attracted considerable attention owing to their unique and idiographic nucleophilic and electrophilic properties in transition-metal-catalyzed chemical transformations. Among the various metal catalysts, palladium...

Recent Expedition inPd‐CatalyzedSonogashira Coupling and Related Processes†

“…Palladium-catalyzed Sonogashira coupling has been extensively investigated and enormous modifications of those catalyst systems have been made since the first report of Sonogashira coupling. This includes the employment of a variety of new cata-lyst systems (including tailor-made Pd-phosphines, [8] Pd-NHCs, [9] palladacycles, [10] Pd-nanoparticles and polymer-supported Pd catalysts, etc.) with unique additives and solvents.…”

A syn outer-sphere oxidative addition: the reaction mechanism in Pd/Senphos-catalyzed carboboration of 1,3-enynes

“… 2 However, synthesis of tetra-substituted alkenes 3 in a stereo-defined manner remains nontrivial. Among numerous methods developed to date, transition metal-catalyzed difunctionalization of alkynes 4 has exhibited remarkable efficiency owing to the simultaneous introduction of two desired units across an alkyne, an inexpensive and readily available feedstock, and therefore has continuously drawn substantial attention. In this context, transition metal-catalyzed carboboration of internal alkynes 5 allows expedient synthesis of tetra-substituted alkenyl boronates 6 which are useful precursors to stereo-defined tetra-substituted alkenes.…”

A Facile synthesis of Biaryl ketones in recyclable system: Triazenes as new coupling partners in the carbonylative Suzuki and Hiyama cross‐coupling reactions using NFSac as CO source

“…reported the palladium‐catalyzed carbonylative Suzuki cross coupling reactions using AFA [8e] and NFSac [8f] respectively as CO surrogates. A catalyst for the carbonylative Suzuki cross coupling reaction, N ‐Heterocylic Carbene‐Palladium (NHC−Pd) [8g–i] complex, was reported by Zheng et. al .…”