Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

Pan, Wei; Rafiq, Muhammad; Haider, Waqas; Guo, Yuanyuan; Wang, Huinan; Xu, Mengyuan; Yu, Bing; Cong, Hailin; Shen, Youqing

doi:10.1016/j.ccr.2024.215907

Coordination Chemistry Reviews

2024

DOI: 10.1016/j.ccr.2024.215907

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Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

Wei Pan,

Muhammad Rafiq,

Waqas Haider

et al.

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Cited by 11 publications

References 192 publications

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Ultra‐Photostable Bacterial‐Seeking Near‐Infrared CPDs for Simultaneous NIR‐II Bioimaging and Antibacterial Therapy

Duan,

Li,

Liu

et al. 2024

Adv Healthcare Materials

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Bacterial infections can pose significant health risks as they have the potential to cause a range of illnesses. These infections can spread rapidly and lead to complications if not promptly diagnosed and treated. Therefore, it is of great significance to develop a probe to selectively target and image pathogenic bacteria while simultaneously killing them, as there are currently no effective clinical solutions available. This study presents a novel approach using near‐infrared carbonized polymer dots (NIR‐CPDs) for simultaneous in vivo imaging and treatment of bacterial infections. The core–shell structure of the NIR‐CPDs facilitates their incorporation into bacterial cell membranes, leading to an increase in fluorescence brightness and photostability. Significantly, the NIR‐CPDs exhibit selective bacterial‐targeting properties, specifically identifying Staphylococcus aureus (S. aureus) while sparing Escherichia coli (E. coli). Moreover, under 808 nm laser irradiation, the NIR‐CPDs exhibit potent photodynamic effects by generating reactive oxygen species that target and damage bacterial membranes. In vivo experiments on infected mouse models demonstrate not only precise imaging capabilities but also significant therapeutic efficacy, with marked improvements in wound healing. The study provides the dual‐functional potential of NIR‐CPDs as a highly effective tool for the advancement of medical diagnostics and therapeutics in the fight against bacterial infections.

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Ultra‐Photostable Bacterial‐Seeking Near‐Infrared CPDs for Simultaneous NIR‐II Bioimaging and Antibacterial Therapy

Duan,

Li,

Liu

et al. 2024

Adv Healthcare Materials

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NIR‐II Fluorescence/Photoacoustic Dual Ratiometric Probes with Unique Recognition Site for Quantitatively Visualizing H₂S₂in Vivo

Hu,

Liu,

Jiang

et al. 2024

Angewandte Chemie

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Hydrogen persulﬁde (H2S2) plays a significant role in redox biology and signal transduction; therefore, quantitative visualization of H2S2 in the deep tissue of living organisms is essential for obtaining reliable information about relevant pathophysiological processes directly. However, currently reported H2S2 probes are unsuitable for this purpose because of their poor selectivity for many polysulfide species or their short wavelength, which hinders precise imaging in deep tissues. Herein, for the first time, we report a unique H2S2‐mediated dithiole formation reaction. Based on this reaction, we construct the first NIR‐II fluorescence (FL) and photoacoustic (PA) dual‐ratiometric probe (NIR‐II‐H2S2) for quantitatively visualizing H2S2 in vivo. This probe shows dual‐ratiometric NIR‐II fluorescence (I840/I1000, 107‐fold) and photoacoustic (PA800/PA900, 6.5‐fold) responses towards Na2S2 species with high specificity, excellent sensitivity (1.8 nM), improved water solubility, and deep‐tissue penetration. More importantly, using NIR‐II dual‐ratiometric FL/PA imaging, we successfully demonstrated that the probe could be used to accurately quantify the fluctuating H2S2 levels in the liver‐injury mouse models induced by lipopolysaccharides or metformin drugs. Overall, this study not only presents a promising tool for H2S2‐related pathological research, but also provides a unique recognition site that may be generalized for designing more useful H2S2 imaging agents in the future.

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NIR‐II Fluorescence/Photoacoustic Dual Ratiometric Probes with Unique Recognition Site for Quantitatively Visualizing H₂S₂in Vivo

Hu,

Liu,

Jiang

et al. 2024

Angew Chem Int Ed

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Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

Cited by 11 publications

References 192 publications

Ultra‐Photostable Bacterial‐Seeking Near‐Infrared CPDs for Simultaneous NIR‐II Bioimaging and Antibacterial Therapy

Ultra‐Photostable Bacterial‐Seeking Near‐Infrared CPDs for Simultaneous NIR‐II Bioimaging and Antibacterial Therapy

NIR‐II Fluorescence/Photoacoustic Dual Ratiometric Probes with Unique Recognition Site for Quantitatively Visualizing H₂S₂in Vivo

NIR‐II Fluorescence/Photoacoustic Dual Ratiometric Probes with Unique Recognition Site for Quantitatively Visualizing H₂S₂in Vivo

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Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

Cited by 11 publications

References 192 publications

Ultra‐Photostable Bacterial‐Seeking Near‐Infrared CPDs for Simultaneous NIR‐II Bioimaging and Antibacterial Therapy

Ultra‐Photostable Bacterial‐Seeking Near‐Infrared CPDs for Simultaneous NIR‐II Bioimaging and Antibacterial Therapy

NIR‐II Fluorescence/Photoacoustic Dual Ratiometric Probes with Unique Recognition Site for Quantitatively Visualizing H2S2in Vivo

NIR‐II Fluorescence/Photoacoustic Dual Ratiometric Probes with Unique Recognition Site for Quantitatively Visualizing H2S2in Vivo

Contact Info

Product

Resources

About

NIR‐II Fluorescence/Photoacoustic Dual Ratiometric Probes with Unique Recognition Site for Quantitatively Visualizing H₂S₂in Vivo

NIR‐II Fluorescence/Photoacoustic Dual Ratiometric Probes with Unique Recognition Site for Quantitatively Visualizing H₂S₂in Vivo