Recent advances in non-contact force sensors used for micro/nano manipulation

Zang, Haoyan; Zhang, Xianmin; Zhu, Benliang; Fatikow, Sergej

doi:10.1016/j.sna.2019.07.007

Cited by 47 publications

(15 citation statements)

References 163 publications

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“…In some fields, it has been regarded as an alternative to electric force sensors. The current main microforce sensor methods are summarized in the literature [115]. However, optical force sensors are easily affected by the reflection and refraction of liquid media (such as in petri dish).…”

Section: Sensors In Cell Microinjectionmentioning

confidence: 99%

A Review of Recent Advances in Robotic Cell Microinjection

Chi

Zhu

2020

IEEE Access

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Cell microinjection is a direct and effective way to transfer external materials into the cell. In the field of modern biomedicine, cell microinjection is very important, no matter in genetics, reproductive health, tumor therapy or others related research directions. Traditional manual cell microinjection has the disadvantages of low efficiency and low survival rate. In contrast, robotic cell microinjection can achieve precise and effective cell microinjection, and can be used in the injection of large quantities of cells. This paper reviews recent advances in robotic cell microinjection technologies. It summarizes the main approaches of key technologies and their advantages and disadvantages, such as cell identification, cell holding, precise positioning platform, cell injection strategy, sensors in cell microinjection, and cell modeling. The conclusion of the investigation is that the robotic cell microinjection has achieved remarkable results and still has great potential for further development. It is expected to be widely used in biomedicine and other fields to realize convenient, fast, and efficient microinjection operations of large number of individual cells. INDEX TERMS Robotic cell microinjection, cell identification, cell holding, precise displacement platform, injection strategy, sensors in cell microinjection, cell modeling.

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Section: Sensors In Cell Microinjectionmentioning

confidence: 99%

A Review of Recent Advances in Robotic Cell Microinjection

Chi

Zhu

2020

IEEE Access

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“…This developed nano-force sensor had ability to detect mechanical coupling between individual DNA molecules and the transistor in pN (10 −12 N) range, which was much more sensitive than silicon nitride/ZnO-based nano-force sensors. More detail of the difference among the three types of force sensors can be found in two previous review works [ 69 , 70 ]. The present work mainly discusses the frequency-based nano-force sensors, i.e., using carbon nanomaterials as resonators for detecting tiny forces from the evaluation of the resonant frequency shifts [ 71 ].…”

Section: Introductionmentioning

confidence: 99%

Review on Carbon Nanomaterials-Based Nano-Mass and Nano-Force Sensors by Theoretical Analysis of Vibration Behavior

Shi

Lei

Natsuki

2021

Sensors

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Carbon nanomaterials, such as carbon nanotubes (CNTs), graphene sheets (GSs), and carbyne, are an important new class of technological materials, and have been proposed as nano-mechanical sensors because of their extremely superior mechanical, thermal, and electrical performance. The present work reviews the recent studies of carbon nanomaterials-based nano-force and nano-mass sensors using mechanical analysis of vibration behavior. The mechanism of the two kinds of frequency-based nano sensors is firstly introduced with mathematical models and expressions. Afterward, the modeling perspective of carbon nanomaterials using continuum mechanical approaches as well as the determination of their material properties matching with their continuum models are concluded. Moreover, we summarize the representative works of CNTs/GSs/carbyne-based nano-mass and nano-force sensors and overview the technology for future challenges. It is hoped that the present review can provide an insight into the application of carbon nanomaterials-based nano-mechanical sensors. Showing remarkable results, carbon nanomaterials-based nano-mass and nano-force sensors perform with a much higher sensitivity than using other traditional materials as resonators, such as silicon and ZnO. Thus, more intensive investigations of carbon nanomaterials-based nano sensors are preferred and expected.

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“…Additionally, sensor interfacing greatly increases the cost of micromanipulation setup. Vision-based displacement sensing is more suitable to use in an aqueous medium [3]. The outstanding advantages of the vision-based displacement sensor are its low cost, ease to implement, high reliability and accuracy [4] and measurement of displacement in three orthogonal axes at once by a single camera.…”

Section: Introductionmentioning

confidence: 99%

Vision-Based Sensor for Three-Dimensional Vibrational Motion Detection in Biological Cell Injection

Sadak

Saadat

Hajiyavand

2019

Sensors

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Intracytoplasmic sperm injection (ICSI) is an infertility treatment where a single sperm is immobilised and injected into the egg using a glass injection pipette. Minimising vibration in three orthogonal axes is essential to have precise injector motion and full control during the egg injection procedure. Vibration displacement sensing using physical sensors in ICSI operation is challenging since the sensor interfacing is not practically feasible. This study proposes a non-invasive technique to measure the three-dimensional vibrational motion of the injection pipette by a single microscope camera during egg injection. The contrast-limited adaptive histogram equalization (CHALE) method and blob analyses technique were employed to measure the vibration displacement in axial and lateral axes, while the actual dimension of the focal axis was directly measured using the Brenner gradient algorithm as a focus measurement algorithm. The proposed algorithm operates between the magnifications range of 4× to 40× with a resolution of half a pixel. Experiments using the proposed vision-based algorithm were conducted to measure and verify the vibration displacement in axial and lateral axes at various magnifications. The results were compared against manual procedures and the differences in measurements were up to 2% among all magnifications. Additionally, the effect of injection speed on lateral vibration displacement was measured experimentally and was used to determine the values for egg deformation, force fluctuation, and penetration force. It was shown that increases in injection speed significantly increases the lateral vibration displacement of the injection pipette by as much as 54%. It has been demonstrated successfully that visual sensing has played a key role in identifying the limitation of the egg injection speed created by lateral vibration displacement of the injection pipette tip.

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Recent advances in non-contact force sensors used for micro/nano manipulation

Cited by 47 publications

References 163 publications

A Review of Recent Advances in Robotic Cell Microinjection

A Review of Recent Advances in Robotic Cell Microinjection

Review on Carbon Nanomaterials-Based Nano-Mass and Nano-Force Sensors by Theoretical Analysis of Vibration Behavior

Vision-Based Sensor for Three-Dimensional Vibrational Motion Detection in Biological Cell Injection

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