Recent advances in optical fiber devices for microfluidics integration

Blue, Robert; Uttamchandani, Deepak

doi:10.1002/jbio.201500170

Cited by 33 publications

(15 citation statements)

References 82 publications

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“…This is a common issue faced by many droplet-based qPCR systems. In future, our platform could be incorporated with microfluidics [ 54 ], which has been demonstrated for other optical fiber systems [ 55 ]. This could allow for low-volume mixing with higher volumetric precision of the multiple components of the PCR reaction mix to allow for sub-microliter sample usage and device reusability.…”

Section: Discussionmentioning

confidence: 99%

All-fiber all-optical quantitative polymerase chain reaction (qPCR)

Nguyen

Hill

et al. 2020

Sensors and Actuators B: Chemical

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Highlights Quantitative polymerase chain reaction (qPCR) in an all-fiber all-optical configuration. Thermal cycling and fluorescence detection in a single optical-fiber-integrated device. Advantages of small sample volume, portability and high-speed operation. Potential ability to operate fluorescence-free through direct measurement of refractive index. Target application is disease and pathogen detection in remote communities.

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Section: Discussionmentioning

confidence: 99%

All-fiber all-optical quantitative polymerase chain reaction (qPCR)

Nguyen

Hill

et al. 2020

Sensors and Actuators B: Chemical

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“…and Lim, 2002;Ko and Grant, 2006;Liu et al, 2003;Ohk and Bhunia, 2012;Sharma and Mutharasan, 2013). At present, the focus is shifting towards the integration of SPR into microfluidic systems to establish versatile lab-on-fibre technology for the POC applications (Blue and Uttamchandani, 2016;Chen et al, 2016;Lin et al, 2015;Luka et al, 2015;Oscar et al, 2017;Ricciardi et al, 2015;Sun et al, 2016;M. Yin et al, 2016).…”

Section: Optical Fibre Biosensorsmentioning

confidence: 99%

Microfluidic devices for sample preparation and rapid detection of foodborne pathogens

Kant

Shahbazi

Dave

et al. 2018

Biotechnology Advances

152

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Rapid detection of foodborne pathogens at an early stage is imperative for preventing the outbreak of foodborne diseases, known as serious threats to human health. Conventional bacterial culturing methods for foodborne pathogen detection are time consuming, laborious, and with poor pathogen diagnosis competences. This has prompted researchers to call the current status of detection approaches into question and leverage new technologies for superior pathogen sensing outcomes. Novel strategies mainly rely on incorporating all the steps from sample preparation to detection in miniaturized devices for online monitoring of pathogens with high accuracy and sensitivity in a time-saving and cost effective manner. Lab on chip is a blooming area in diagnosis, which exploits different mechanical and biological techniques to detect very low concentrations of pathogens in food samples. This is achieved through streamlining the sample handling and concentrating procedures, which will subsequently reduce human errors and enhance the accuracy of the sensing methods. Integration of sample preparation techniques into these devices can effectively minimize the impact of complex food matrix on pathogen diagnosis and improve the limit of detections. Integration of pathogen capturing bio-receptors on microfluidic devices is a crucial step, which can facilitate recognition abilities in harsh chemical and physical conditions, offering a great commercial benefit to the food-manufacturing sector. This article reviews recent advances in current state-of-the-art of sample preparation and concentration from food matrices with focus on bacterial capturing methods and sensing technologies, along with their advantages and limitations when integrated into microfluidic devices for online rapid detection of pathogens in foods and food production line.

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“…However, as mentioned above, this type of biosensors might be affected by nonspecific refractive index changes in the employed GO, which can be triggered by temperature changes. [91] Chen and co-workers explored an optical fiber (particularly, dual-peak long-period grating) decorated with GO and antibodies targeting anti-IgG, see Figure 5A. Surface plasmon resonance (SPR) biosensors and optical waveguide biosensors rely on the aforementioned refractive index-dependent biosensing mechanism.…”

Section: Go In Label-free Optical Biosensingmentioning

confidence: 99%

Graphene Oxide as an Optical Biosensing Platform: A Progress Report

2018

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IntroductionAs a 2D material, graphene oxide (GO) is a lattice-like nanostructure of hexagonal carbon rings disrupted by oxygen-containing moieties. In 2012, we discussed the outstanding physicochemical properties offered by GO and how these features can be exploited in unprecedented optical biosensing systems. [1] In fact, GO can be processed in suspension, easily complexed with biomolecules, and offers a universal highly efficient long-range photoluminescence quenching agent-among other functional properties. Furthermore, we highlighted that GO photoluminescences with energy transfer donor/acceptor molecules exposed A few years ago, crucial graphene oxide (GO) features such as the carbon/oxygen ratio, number of layers, and lateral size were scarcely investigated and, thus, their impact on the overall optical biosensing performance was almost unknown. Nowadays valuable insights about these features are well documented in the literature, whereas others remain controversial. Moreover, most of the biosensing systems based on GO were amenable to operating as colloidal suspensions. Currently, the literature reports conceptually new approaches obviating the need of GO colloidal suspensions, enabling the integration of GO onto a solid phase and leading to their application in new biosensing devices. Furthermore, most GO-based biosensing devices exploit photoluminescent signals. However, further progress is also achieved in powerful label-free optical techniques exploiting GO in biosensing, particularly using optical fibers, surface plasmon resonance, and surface enhanced Raman scattering. Herein, a critical overview on these topics is offered, highlighting the key role of the physicochemical properties of GO. New challenges and opportunities in this exciting field are also highlighted.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201805043.in a planar surface. [1] However, GO properties can be tailored according to its oxidation degree, lateral size, and number of layers, which was something little explored 6 years ago, and thus their impact on the overall biosensing performance was almost unknown. In addition, most of the biosensing systems based on GO were amenable to working as colloidal suspensions. Though, recent literature reports conceptually new approaches obviating the need of colloidal suspensions, which facilitates integration of GO-based biosensors into the solid phase and allows for their applications in new devices. Furthermore, the majority of the GO-based optical biosensing techniques rely on photoluminescent signals. However, further progress has also been achieved in powerful label-free optical techniques exploiting GO in biosensing. Here, we introduce a progress report on this exciting topic, underscoring challenges and opportunities in (bio)sensing accordingly. Number of LayersGO aqueous suspensions are highly stable in the form of mono layers. However, GO multilayer films can be built via

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Recent advances in optical fiber devices for microfluidics integration

Cited by 33 publications

References 82 publications

All-fiber all-optical quantitative polymerase chain reaction (qPCR)

All-fiber all-optical quantitative polymerase chain reaction (qPCR)

Microfluidic devices for sample preparation and rapid detection of foodborne pathogens

Graphene Oxide as an Optical Biosensing Platform: A Progress Report

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