Recent advances in oral mucosal research

Mackenzie, Ian C.; Binnie, William H.

doi:10.1111/j.1600-0714.1983.tb00353.x

Cited by 14 publications

(9 citation statements)

References 207 publications

(175 reference statements)

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“…(18). Merkel cells, which are clustered in rele ridges or fouriil singly in the basal layer (8,19,20) seemed to be extremely rare or lo be negative for SlOO-protein in human tongue, as concluded from the fact that we could not find Sl(K)-protein positive cells that showed such a distribution in normal mucosal epithelium of the tongue at a great distance from cancerous lesions.…”

Section: Methodsmentioning

confidence: 82%

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The pathological significance of Langerhans cells in oral cancer

Kurihara

Hashimoto

1985

J Oral Pathology Medicine

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The functional role of Langerhans cells (LCs) in oral cancer was studied, based on a quantitative analysis of LCs in squamous cell carcinomas arising from the tongue. LCs were identified by their positiveness for S100‐protein and other cytological characters based on PAP method. LCs increased in number in the cancer region and showed an intimate relationship with lymphocytes in terms of their number and distribution. Moreover, in those cases with many LCs, clusters consisting of LCs and lymphocytes were often found to combine into “hydropic degeneration‐like” lesions as seen in allergic disease such as dermal lichen planus. These findings, as well as the review of literature, suggested some immunological role of LCs in oral carcinoma.

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Section: Methodsmentioning

confidence: 82%

“…Langerhans cells (LCs) are now eonsidered to be antigen-presenting cells to lymphocytes in the skin or oral mucosa (1)(2)(3)(4)(5)(6)(7)(8). Although an immunological function of LCs has been proven in eontact dermatitis (1.…”

mentioning

confidence: 99%

The pathological significance of Langerhans cells in oral cancer

Kurihara

Hashimoto

1985

J Oral Pathology Medicine

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“…In an attempt to measure the ion transport properties of the buccal epithelium, Kaaber performed a series of studies examining electrolyte uptake from the mucosal surface onto filter paper, which was subsequently analyzed for sodium and potassium content using a flame photometer (Kaaber, 1974). Kaaber did not observe electrolyte transport in this assay; which led to a prevailing concept that ion transport in the buccal mucosa occurred via passive diffusion (Kaaber, 1974; Mackenzie and Binnie, 1983; Siegal, 1984). However, additional studies have not confirmed this finding, and indeed, they have provided strong evidence that the oral mucosa does indeed actively transport salts similar to other stratified squamous epithelial tissues such as esophagus and cornea.…”

Section: Ion Transport Properties Of the Oral Mucosamentioning

confidence: 84%

The oral mucosa as a therapeutic target for xerostomia

et al. 2008

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Autoimmune disorders, medical interventions, and aging are all known to be associated with salivary gland hypofunction, which results in the uncomfortable feeling of dry mouth (xerostomia) and significantly diminished oral health. The current therapeutic regimen includes increasing oral hydration using over-the-counter oral comfort agents and the use of systemic cholinergic drugs to stimulate salivary output. However, these approaches produce very transient relief or are associated with uncomfortable side-effects. Thus, new treatments that provide long-lasting relief from discomfort and improve oral health with minimal side-effects would benefit the therapy of this disease. The processes that mediate fluid loss from the oral cavity, such as the absorption of fluid from the oral mucosa, represent novel therapeutic targets for xerostomia. Preventing fluid absorption from the oral cavity is predicted to improve oral hydration and alleviate the clinical symptoms and discomfort associated with dry mouth. Furthermore, therapeutic strategies that prevent fluid absorption should complement current approaches that increase salivary output. This review discusses the current understanding of oral fluid balance and how these processes may be manipulated to provide relief for those suffering from dry mouth.

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“…Studies from several different laboratories around the world using various murine epithelia, i.e. IFE and hair follicle of the skin, small intestine and oral mucosa of the tongue (29–37) convincingly show that the proliferative compartment is not a homogeneous pool of dividing cells in vivo. Specifically, marking cycling cells in S‐phase in adult mice by means of a single 3 H‐Tdr or BrDU injection and then following these labelled cells over time demonstrate the existence of at least one group of rapidly cycling and short‐lived cells, while persistent labelling in neonatal mice followed by a significantly long chase period (12 weeks) reveals the existence of label‐retaining cells (LRCs) interpreted to be quiescent or more accurately put relatively slower cycling and/or capable of segregating their parental DNA strand (38).…”

Section: Please Sir May I Be Excused – My Brain Is Full! the Need Tomentioning

confidence: 99%

The interfollicular epidermal stem cell saga: sensationalism versus reality check

Kaur

Potten

2011

Experimental Dermatology

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Adult stem cells in rapidly renewing tissues have been classically defined as rare, relatively quiescent cells with the unique capacity to constantly self-renew and regenerate tissues during homeostasis. Although this view remains firmly embedded in the skin field, particularly in the area of hair follicle stem cell biology, it has been challenged by a number of notable publications in 2007. These papers leave an uncomfortable feeling with the reader if one believes that stem cells and transit amplifying cells are two polar opposites and 'never the twain shall meet.' Even if you do not subscribe to this extreme view, the implications appear to be far-reaching given that the majority of techniques devised for stem cell identification have used the fundamental tenet that the proliferating compartment is comprised of two distinct, mutually exclusive compartments, i.e. a minor proportion of long-lived quiescent stem cells with unlimited self-renewal and a large pool of rapidly cycling, shortlived transient amplifying cells with limited or no self-renewal capacity in normal steady-state conditions. However, these recent findings have resulted in papers that could be described as sensationalistic because they make little or no attempt to reconcile their observations with the large bulk of historical data with direct bearing on the interpretation of stem cell activity in normal steady-state conditions. Here, we offer some explanations that may help to integrate all of the data while presenting a case that both quiescent stem cells and cycling 'transit amplifying' cells contribute to epidermal replacement.

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Recent advances in oral mucosal research

Cited by 14 publications

References 207 publications

The pathological significance of Langerhans cells in oral cancer

The pathological significance of Langerhans cells in oral cancer

The oral mucosa as a therapeutic target for xerostomia

The interfollicular epidermal stem cell saga: sensationalism versus reality check

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