Recent Advances in Pharmaceutical Applications of Natural Carbohydrate Polymer Gum Tragacanth

Dhupal, Madhusmita; Gupta, Mukesh Kumar; Tripathy, Dipti Ranjan; Kumar, M. Mahesh; Yi, Dong Kee; Nanda, Sitansu Sekhar; Chowdhury, Devasish

doi:10.1201/9780429328251-3

Cited by 4 publications

(3 citation statements)

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“…The systemic bioavailability of this compound, which apparently manifests itself at a low plasma concentration, is an additional problem in experimental research on the effects of curcumin in humans. Optimizing the bioavailability of curcumin using various drug delivery strategies provides more relevant results, highlighting that in vitro/in vivo anti-tumor activity can be repelled in the clinical context by addressing different pharmacological strategies [132,133].…”

Section: Clinical Trialsmentioning

confidence: 99%

Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer

et al. 2021

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Breast cancer (BC) is one of the most common type of cancer and an important contributor to female mortality. Several genes and epigenetic modifications are involved in the development and progression of BC. Research in phytochemistry, nutrigenomics, and nutrigenetics has provided strong evidence that certain phytonutrients are able to modulate gene expression at transcriptional and post-transcriptional levels. Such phytonutrients may also be beneficial to prevent and treat BC. In this review, we will focus on the nutrigenomic effects of various phytochemicals including polyphenols, phytosterols, terpenoids, alkaloids, and other compounds from different sources. Overall, these phytonutrients are found to inhibit BC cell proliferation, differentiation, invasion, metastasis, angiogenesis, and induce apoptotic cell death by targeting various molecular pathways. They also alter epigenetic mechanisms and enhance the chemosensitivity and radiosensitivity of cancer cells. Such phytochemicals may be used for the effective management of BC patients in the clinical setting in the future. The present article aims to summarize the specific molecular pathways involved in the genetic effects of phytochemicals in BC.

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Section: Clinical Trialsmentioning

confidence: 99%

Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer

et al. 2021

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“…[10][11][12] A wide spectrum of clinical trials has detected significant anticancer properties of various phytochemicals, which are currently in clinical use. 13 As indicated in Figure 3, a wide array of secondary plant metabolites (phenols, alkaloids, flavonoids, flavonols, terpenoids, terpenes, steroids, flavonolignans, and organosulfur compounds) have been identified, isolated, characterized and investigated clinically for their use in cancer therapy (Figure 3). For example, phytobioactive compounds such as; epigallocatechin gallate (EGCG), a polyphenol isolated from Camellia sinensis (Tea); genistein, a soy isoflavonoid derived from Glycin max Linn.…”

Section: Phytochemicals As Cell Cycle Arrest and Apoptotic Cell Deathmentioning

confidence: 99%

“…In recent years, combinatorial therapy is being used in clinics in which phytocompounds are used in conjugation with other chemopreventives to achieve higher cancer sensitivity compared to single drugs. 13,14 To date, more than hundreds of phytochemicals (eg, topotecan, irinotecan HCl, vincristine sulfate, vinorelbine tartrate, vinflunine ditartrate, ingenol mebutate, maytansine, sulforaphane, curcumin, paclitaxel, etc.) have been approved by US FDA and currently, in clinical use as potent anticancer drugs, 2,7 compiled in Table 2.…”

Section: Figurementioning

confidence: 99%