Recent Advances in Phenolic Metabolites and Skin Cancer

Abstract

Skin cancer represents any tumor development from the cutaneous structures within the epidermis, dermis or subcutaneous tissue, and is considered to be the most prevalent type of cancer. Compared to other types of cancer, skin cancer is proven to have a positive growth rate of prevalence and mortality. There are available various treatments, including chemotherapy, immunotherapy, radiotherapy and targeted therapy, but because of the multidrug resistance development, a low success has been registered. By this, the importance of studying naturally occurring compounds that are both safe and effective in the chemoprevention of skin cancer is emphasized. This review focuses on melanoma because it is the deadliest form of skin cancer, with a significantly increasing incidence in the last decades. As chemopreventive agents, we present polyphenols and their antioxidant activity, anti-inflammatory effect, their ability to balance the cell cycle and to induce apoptosis and their various other effects on skin melanoma. Besides chemoprevention, studies suggest that polyphenols can have treating abilities in some conditions. The limitations of using polyphenols are also pointed out, which are related to their poor bioavailability and stability, but as the technology is well developed, it is possible to augment the efficacy of polyphenols in the case of melanoma.

The Apoptotic Effect of Caffeic or Chlorogenic Acid on the C32 Cells That Have Simultaneously Been Exposed to a Static Magnetic Field

“…In addition, the use of natural compounds might reduce the side effects of standard therapy. Previous studies have shown that polyphenols demonstrate anticancer properties on melanoma cell lines via their cytotoxic and anti-proliferative effects and also by participating in the regulation of cell cycle, apoptosis and autophagy [ 22 ]. Martino et al [ 23 ] suggested that the extract from Larrea divaricata Cav.…”

Review and Chemoinformatic Analysis of Ferroptosis Modulators with a Focus on Natural Plant Products

“…Polyphenols have already been used in dermatology and are known to exert antiproliferative, proapoptotic, and antimetastatic activities on melanoma cell lines, whereas they have no cytotoxic effect in healthy cells [ 53 , 54 ]. Since ferroptotic pathways contribute to the regulation of the differentiation state of melanoma cells and their resistance to certain therapeutic agents, ferroptosis inducers are expected to have strong therapeutic potential in melanoma [ 55 ].…”

Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review

“…In terms of health properties, many studies have demonstrated their various biological activities including anti-inflammatory, anticancer, antibacterial and antiviral properties. Specific flavonoids were described to function as antioxidants, enzyme inhibitors, epigenetic modulators or even suppressors in some signaling pathways [72,73].…”