Recent advances in plant polysaccharide-mediated nano drug delivery systems

Zheng, Yu; Xie, Qingxuan; Wang, Hong; Hu, Yanjun; Ren, Bo; Li, Xiaofang

doi:10.1016/j.ijbiomac.2020.10.173

Cited by 74 publications

(23 citation statements)

References 87 publications

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“…[ 38 ] Due to their natural origin, some are extracted from plants or animals, while some are obtained from bacterial fermentation processes. [ 108,109 ] Hence, it is difficult to perform batch‐to‐batch quality control and to characterize the properties of these natural polysaccharides. [ 38 ] Hyaluronic acid, for example, comes with a molecular weight ranging from 5 to 20 000 kDa in vivo.…”

Section: Discussionmentioning

confidence: 99%

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Niu

Xue

2021

Macromolecular Bioscience

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Inflammation is closely related to a variety of fatal or chronic diseases. Hence, targeting inflammation provides an alternative approach to improve the therapeutic outcome of diseases such as solid tumors, neurological diseases, and metabolic diseases. Polysaccharides are natural components with immune regulation, anti‐virus, anti‐cancer, anti‐inflammation, and anti‐oxidation activities. Herein, this review highlights recent progress in the polysaccharide‐based drug delivery systems for achieving inflammation targeting and its related disease treatment. Moreover, the chemical modification and the construction of polysaccharide materials for drug delivery are discussed in detail.

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Section: Discussionmentioning

confidence: 99%

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Niu

Xue

2021

Macromolecular Bioscience

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“…Usually, such natural polysaccharides are easily available from the plant, animals and microbes. Such polysaccharides possess various physicochemical properties such as being neutral or having positive or negative charge, being able to have linear or branched molecular structure, and their molecular weight can vary from a few hundred to several thousand Daltons [5][6][7]. Due to these properties, the polysaccharides have considerable impact on the biodistribution of carrier drug molecules in-vivo [8,9].…”

Section: Introductionmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

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“…The utilization of polysaccharides as a carrier for anticancer drugs has attracted much attention over the past decade [ 8 , 9 ]. Polysaccharides from macro-fungi might be utilized as a multi-purpose prescription in the future decade [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Polysaccharides from macro-fungi might be utilized as a multi-purpose prescription in the future decade [ 10 ]. Furthermore, with the rapid advancement of science and medicine, plant polysaccharide research has become increasingly important [ 8 , 11 ]. Despite the fact that there are many unexplained mysteries in this regard, plant polysaccharides have therapeutic effects and a wide range of applications, making them an essential route for developing novel drugs.…”

Section: Introductionmentioning

confidence: 99%

Recent Advancements in Microbial Polysaccharides: Synthesis and Applications

et al. 2021

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Polysaccharide materials are widely applied in different applications including food, food packaging, drug delivery, tissue engineering, wound dressing, wastewater treatment, and bioremediation sectors. They were used in these domains due to their efficient, cost-effective, non-toxicity, biocompatibility, and biodegradability. As is known, polysaccharides can be synthesized by different simple, facile, and effective methods. Of these polysaccharides are cellulose, Arabic gum, sodium alginate, chitosan, chitin, curdlan, dextran, pectin, xanthan, pullulan, and so on. In this current article review, we focused on discussing the synthesis and potential applications of microbial polysaccharides. The biosynthesis of polysaccharides from microbial sources has been considered. Moreover, the utilization of molecular biology tools to modify the structure of polysaccharides has been covered. Such polysaccharides provide potential characteristics to transfer toxic compounds and decrease their resilience to the soil. Genetically modified microorganisms not only improve yield of polysaccharides, but also allow economically efficient production. With the rapid advancement of science and medicine, biosynthesis of polysaccharides research has become increasingly important. Synthetic biology approaches can play a critical role in developing polysaccharides in simple and facile ways. In addition, potential applications of microbial polysaccharides in different fields with a particular focus on food applications have been assessed.

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Recent advances in plant polysaccharide-mediated nano drug delivery systems

Cited by 74 publications

References 87 publications

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Current-status and applications of polysaccharides in drug delivery systems

Recent Advancements in Microbial Polysaccharides: Synthesis and Applications

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