Recent Advances in Polyanhydride Based Biomaterials

Basu, Arijit; Domb, Abraham J.

doi:10.1002/adma.201706815

Cited by 71 publications

(113 citation statements)

References 93 publications

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“…By this mechanism, such particle-associated insecticides may reduce the amount of active ingredient needed to kill pests and/or reduce the risk of environmental contamination by pesticides and associated vertebrate toxicity [7]. Biodegradable polyanhydride particles [8,9], synthesized from copolymers of 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG), 1,6-bis(p-carboxyphenoxy)hexane (CPH), and sebacic acid (SA) monomers, represent promising delivery technologies for novel insecticides. These biocompatible carriers [10,11] encapsulate small molecule, nucleic acid, or protein payloads within a hydrophobic (or amphiphilic) polymer matrix, react with water to hydrolyze their anhydride bonds, and gradually release their payload as the polymer degrades [12][13][14] The payload release kinetics of these carriers can be tuned from hours to several months based on polymer degradation kinetics, device size, and understanding of polymer-payload interactions [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Biodistribution of degradable polyanhydride particles in Aedes aegypti tissues

et al. 2020

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Insecticide resistance poses a significant threat to the control of arthropods that transmit disease agents. Nanoparticle carriers offer exciting opportunities to expand the armamentarium of insecticides available for public health and other pests. Most chemical insecticides are delivered by contact or feeding, and from there must penetrate various biological membranes to reach target organs and kill the pest organism. Nanoparticles have been shown to improve bioactive compound navigation of such barriers in vertebrates, but have not been well-explored in arthropods. In this study, we explored the potential of polyanhydride microand nanoparticles (250 nm-3 μm), labeled with rhodamine B to associate with and/or transit across insect biological barriers, including the cuticle, epithelium, midgut and ovaries, in female Ae. aeygpti mosquitoes. Mosquitoes were exposed using conditions to mimic surface contact with a residual spray or paint, topical exposure to mimic contact with aerosolized insecticide, or per os in a sugar meal. In surface contact experiments, microparticles were sometimes observed in association with the exterior of the insect cuticle. Nanoparticles were more uniformly distributed across exterior tissues and present at higher concentrations. Furthermore, by surface contact, topical exposure, or per os, particles were detected in internal organs. In every experiment, amphiphilic polyanhydride nanoparticles associated with internal tissues to a higher degree than hydrophobic nanoparticles. In vitro, nanoparticles associated with Aedes aegypti Aag2 cells within two hours of exposure, and particles were evident in the cytoplasm. Further studies demonstrated that particle uptake is dependent on caveolae-mediated endocytosis. The propensity of these nanoparticles to cross biological barriers including the cuticle, to localize in target tissue sites of interest, and to reach the cytoplasm of cells, provides great promise for targeted delivery of insecticidal candidates that cannot otherwise reach these cellular and subcellular locations.

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Section: Introductionmentioning

confidence: 99%

Biodistribution of degradable polyanhydride particles in Aedes aegypti tissues

et al. 2020

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“…Many polymers have been used to evaluate particulate associated strategies including poly-amino acids (e.g., polylysine), poly-esters (e.g., poly(lactic-co-glycolic) acid (PLGA) [ 102 , 103 , 104 , 105 ], polylactic acid (PLA) [ 106 ] and poly(ester amide)) [ 107 ], polycaprolactone (PCL) [ 105 , 108 , 109 ], polyanhydrides (e.g., poly(carboxyphenoxy propane-co-sebacic acid)) [ 110 ] and carbohydrates (e.g., cyclodextrin [ 111 ]). Most of these polymers are not water-soluble necessitating the use of organic solvents during particle fabrication, which is typically deleterious for proteins, but generally acceptable for peptides.…”

Section: General Strategies To Increase Duration Of Actionmentioning

confidence: 99%

Injectables and Depots to Prolong Drug Action of Proteins and Peptides

et al. 2020

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Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and formulation. Polypeptides often display poor pharmacokinetics, limited permeability across biological barriers, suboptimal biodistribution, and some proclivity for immunogenicity. Frequent administration of polypeptides is generally required to maintain adequate therapeutic levels, which can limit efficacy and compliance while increasing adverse reactions. Many strategies to increase the duration of action of therapeutic polypeptides have been described with many clinical products having been developed. This review describes approaches to optimise polypeptide delivery organised by the commonly used routes of administration. Future innovations in formulation may hold the key to the continued successful development of proteins and peptides with optimal clinical properties.

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“…For the first time, Polyanhydride, one type of degradable synthetic biopolymers, were fabricated through activation of the aromatic dicarboxylic acids using acetic anhydride. Good mechanical properties, prolonged shelf-life and degradation time of different types of polyanhydride polymers make them good candidates for the controlled delivery of drugs [70]. Most Polyanhydride polymers can be synthesized via simple reactions of activated dicarboxylic acids under vacuum and heat.…”

Section: Polyanhydride Polymersmentioning

confidence: 99%

Tailoring synthetic polymeric biomaterials towards nerve tissue engineering: a review

Amani

Kazerooni

Hassanpoor

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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The nervous system is known as a crucial part of the body and derangement in this system can cause potentially lethal consequences or serious side effects. Unfortunately, the nervous system is unable to rehabilitate damaged regions following seriously debilitating disorders such as stroke, spinal cord injury and brain trauma which, in turn, lead to the reduction of quality of life for the patient. Major challenges in restoring the damaged nervous system are low regenerative capacity and the complexity of physiology system. Synthetic polymeric biomaterials with outstanding properties such as excellent biocompatibility and non-immunogenicity find a wide range of applications in biomedical fields especially neural implants and nerve tissue engineering scaffolds. Despite these advancements, tailoring polymeric biomaterials for design of a desired scaffold is fundamental issue that needs tremendous attention to promote the therapeutic benefits and minimize adverse effects. This review aims to (i) describe the nervous system and related injuries. Then, (ii) nerve tissue engineering strategies are discussed and (iii) physiochemical properties of synthetic polymeric biomaterials systematically highlighted. Moreover, tailoring synthetic polymeric biomaterials for nerve tissue engineering is reviewed.

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Recent Advances in Polyanhydride Based Biomaterials

Cited by 71 publications

References 93 publications

Biodistribution of degradable polyanhydride particles in Aedes aegypti tissues

Biodistribution of degradable polyanhydride particles in Aedes aegypti tissues

Injectables and Depots to Prolong Drug Action of Proteins and Peptides

Tailoring synthetic polymeric biomaterials towards nerve tissue engineering: a review

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