Recent Advances in Polymer-based Wound Dressings for the Treatment of Diabetic Foot Ulcer: An Overview of State-of-the-art

Abstract

In summary, this review enlightens the most recent developments in polymer-based wound dressings with special emphasis on advanced polymeric biomaterials, innovative therapeutic strategies and delivery approaches for the treatment of DFUs.

Therapeutic compression materials and wound dressings for chronic venous insufficiency: A comprehensive review

“…Bioactive wound dressings generally comprise antimicrobial dressings (Alavi et al, ; Marston, Tang, Kirsner, & Ennis, ), drug‐released dressings (Jull et al, ; Stana et al, ), and nutrition‐providing dressings (Ray & Kalia, ). Recently, Hussain et al systematically reviewed and reported a number of convincing evidences for bioactive materials embedded polymer‐based chronic wound healing modalities, as well as the latest and innovative therapeutic strategies for management of chronic nonhealing wounds (Hussain, Thu, Shuid, Katas, & Hussain, ; Shao et al, ). Related studies also introduced technical solutions in development of different biomaterials used in wounds healings (Mir et al, ; Murray, West, Cowin, & Farrugia, ; Pop & Almquist, ).…”

<p>Assessment of acceptability and ease of use of gelling fiber dressings in the management of heavily exuding wounds</p>

“…A versatile range of naturally-originated polymers including chitosan, hyaluronic acid, cellulose, alginate, dextran, collagen, gelatin, elastin, fibrin, and silk fibroin has been developed as wound dressings recently. 46 These polymers have been used in the form of hydrogels, films, hydrocolloids, foams, membranes, scaffolds, micro-particles, and nano-particles for wounds and can play a role in wound exudate management, while at the same time enhancing wound healing by delivery of essential wound modulatory peptides and anti-bacterial drugs. Chitosan is the newest naturally occurring polymer that has been potentially developed into forms of dressings that can deliver inflamation regulatory peptides such as neurotensin to accelerate wound healing.…”

Smart Wound Dressings for Diabetic Chronic Wounds

“…Gelatin is a collagen derivative and is applicable to wounds that need a more hydrogel-like material. It is biocompatible and degradable in physiological medium and can mimic many of the characteristics of the dermis [40]. A research group that used bFGF-impregnated gelatin microspheres found that gelatin stimulates angiogenesis and fibroblast proliferation [41].…”

“…Hyaluronic acid (HA) presents a wide range of natural healing properties such as tissue integrity, lubrication, and water absorption. Similar to collagen, HA promotes mesenchymal and epithelial cell migration and differentiation, ultimately improving collagen deposition and angiogenesis for repair [40]. HA's properties are sensitive to molecular weight, however.…”

“…A porous, hydrophobic contact layer is needed to create a barrier between the outside environment and wound, while promoting sterility and reendothelialization. A hydrogel or nonstick material is best to prevent further damage to the granulated area [40]. A second and third layer is needed and relies on fibers oriented specifically to provide channels that can wick away wound exudate both vertically and horizontally.…”