Recent Advances in Polymer Drug Conjugates

Abstract

Polymer drug conjugates play an important role in the delivery of drugs. In the polymeric drug conjugates, the bioactive agent is combined covalently with polymer to achieve the efficient delivery of bioactive agents in the required or specific period of time along with the enhancement of permeability and retention time. A large number of biodegradable polymers have been widely used in the area of biomedical science. Among them, polyphosphazene, is a biodegradable polymer having versatile nature because of its two chlorine atoms attached on both sides of phosphorus atom of its polymeric backbone, it can be easily replaced by nucleophilic substitution reaction. A plenty of work has been explored for its biomedical applications such as tissue engineering, vaccine drug delivery, polyphosphazene- anticancer drug conjugates with doxorubicin, paclitaxel, platinum complexes, methotrexate and gemcitabine for the targeted drug delivery etc. This review is focused on the recent advances in the biomedical applications of polyphosphazene-drug conjugates.

Effect of XlogP and Hansen Solubility Parameters on Small Molecule Modified Paclitaxel Anticancer Drug Conjugates Self-Assembled into Nanoparticles

“…Although many polymer-drug conjugates have been reported to self-assemble forming nanomedicines by themselves, the drug occupancy rate of these polymer-drug conjugates is not very high since the molecular weight of the polymer is higher than that of the anticancer drug. 7,8 In order to increase the drug occupancy rate, small molecule modified anticancer drug conjugates (SMMDCs), which have a higher drug occupancy, have been synthesized. Interestingly, these SMMDCs can self-assemble into NPs in water and the antitumor activity of these SMMDCs was confirmed in vitro and in vivo.…”

“…Although many polymer-drug conjugates have been reported to self-assemble forming nanomedicines by themselves, the drug occupancy rate of these polymer-drug conjugates is not very high since the molecular weight of the polymer is higher than that of the anticancer drug. , …”

Cyclotriphosphazene-based Derivatives for Antibacterial Applications: An Update on Recent Advances

“…With six chemically active chlorine atoms, the cyclotriphosphazene core can undergo substitution reactions to yield various derivatives [31,32]. The synthesis of HCCP-based antibacterial derivatives is mainly focused on nucleophilic substitution reactions…”

Synthesis of Tridecaptin–Antibiotic Conjugates with in Vivo Activity against Gram-Negative Bacteria

“…We postulated that covalently linking tridecaptin A 1 to antibiotics typically used in the treatment of Gram-positive infections would facilitate their passage across the OM of Gram-negative bacteria. This Trojan horse approach has been previously performed through covalent linkage of antibiotics to siderophores, , cell penetrating peptides, , and polymers . This method could also offer some advantages over the coadministration of H-TriA 1 with antibiotics.…”