Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms

Abstract

In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-molecule antimicrobial peptides have a wide variety of antimicrobial spectra and multiple innovative antimicrobial mechanisms due to their rich structural diversity. Consequently, they have become a new research hotspot and are considered to be promising candidates for next-generation antibiotics. Therefore, we have compiled a collection of small-molecule antimicrobial peptides derived from marine microorganisms from the last fifteen years to show the recent advances in this field. We categorize these compounds into three classes—cyclic oligopeptides, cyclic depsipeptides, and cyclic lipopeptides—according to their structural features, and present their sources, structures, and antimicrobial spectrums, with a discussion of the structure activity relationships and mechanisms of action of some compounds.

Characterization of a Novel Antimicrobial Peptide Bacipeptin against Foodborne Pathogens

“…13,14 In general, most of marine antimicrobial peptides are isolated from animals, 15,16 and marine microorganisms are also a hot spot for screening novel antimicrobial peptides. 17,18 In our present study, a Bacillus licheniformis (B. licheniformis) M1 was isolated from the sediment of a deep-sea cold spring, which exhibited obvious antimicrobial activities against foodborne pathogens. The corresponding antimicrobial peptide was purified and the sequence of it was analyzed by tandem mass spectrometry (MS).…”

“…Due to the largely unexplored biodiversity and unique environment, marine habitats have offered a tremendous treasure to discover novel drugs, such as alkaloids, peptides, terpenes, polysaccharides, and quinones. Among them, antimicrobial peptides are of interest because of low ability to induce drug resistance. , In general, most of marine antimicrobial peptides are isolated from animals, , and marine microorganisms are also a hot spot for screening novel antimicrobial peptides. , In our present study, a Bacillus licheniformis (B. licheniformis) M1 was isolated from the sediment of a deep-sea cold spring, which exhibited obvious antimicrobial activities against foodborne pathogens.…”

Antimicrobial therapy based on self-assembling peptides

“…In addition to its rapid broad-spectrum activity against Gram-negative and positive bacteria, fungi, parasites, viruses, and tumor cells, AMP mediates chemotaxis, apoptosis, immune regulation, and wound healing. 3–5 As of January 2023, the Antimicrobial Peptide Database (APD, ) lists 3569 natural antimicrobial peptides. Due to the advantages of broad-spectrum antibacterial activity, unique antibacterial mechanism, less prone to drug resistance, easy synthesis and modification, it has become a new antibacterial material with high development prospects.…”