Recent advances in polysulfide-based prodrug nanomedicines for cancer therapy

Wang, Chao; Sui, Wenxia; Chen, Wujun; Zhang, Yujing; Xing, Jiyao; Jiang, Hongfei; Xu, Wen; Xing, Dongming

doi:10.1016/j.ccr.2024.216138

Coordination Chemistry Reviews

2024

DOI: 10.1016/j.ccr.2024.216138

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Recent advances in polysulfide-based prodrug nanomedicines for cancer therapy

Chao Wang,

Wenxia Sui,

Wujun Chen

et al.

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Overcoming Challenges in Small-Molecule Drug Bioavailability: A Review of Key Factors and Approaches

Wu,

Kwon,

Zhou

et al. 2024

IJMS

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The bioavailability of small-molecule drugs remains a critical challenge in pharmaceutical development, significantly impacting therapeutic efficacy and commercial viability. This review synthesizes recent advances in understanding and overcoming bioavailability limitations, focusing on key physicochemical and biological factors influencing drug absorption and distribution. We examine cutting-edge strategies for enhancing bioavailability, including innovative formulation approaches, rational structural modifications, and the application of artificial intelligence in drug design. The integration of nanotechnology, 3D printing, and stimuli-responsive delivery systems are highlighted as promising avenues for improving drug delivery. We discuss the importance of a holistic, multidisciplinary approach to bioavailability optimization, emphasizing early-stage consideration of ADME properties and the need for patient-centric design. This review also explores emerging technologies such as CRISPR-Cas9-mediated personalization and microbiome modulation for tailored bioavailability enhancement. Finally, we outline future research directions, including advanced predictive modeling, overcoming biological barriers, and addressing the challenges of emerging therapeutic modalities. By elucidating the complex interplay of factors affecting bioavailability, this review aims to guide future efforts in developing more effective and accessible small-molecule therapeutics.

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Overcoming Challenges in Small-Molecule Drug Bioavailability: A Review of Key Factors and Approaches

Wu,

Kwon,

Zhou

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Recent advances in polysulfide-based prodrug nanomedicines for cancer therapy

Cited by 1 publication

References 96 publications

Overcoming Challenges in Small-Molecule Drug Bioavailability: A Review of Key Factors and Approaches

Overcoming Challenges in Small-Molecule Drug Bioavailability: A Review of Key Factors and Approaches

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