Recent Advances in Probiotics as Live Biotherapeutics Against Gastrointestinal Diseases

Kota, Rohini Krishna; Ambati, Ranga Rao; Y, Aswani Kumar; Krupanidhi, S.; Reddy, Prakash Narayana

doi:10.2174/1381612824666180717105128

Cited by 17 publications

(5 citation statements)

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“…salicinius AP-32, L. rhamnosus CT-53, L. paracasei ET-66 and B. animalis subsp. lactis CP-9 show strong antibacterial activity against oral pathogens Due to the slow progress in the discovery of novel antibiotics and rapidly emerging antibiotic resistance in pathogens, living therapeutics have attracted increasing attention recently (Kota et al 2018). Probiotics are natural symbiotic microbes that reside in the gut, skin and mucosal tissue, and their use in oral healthcare is considered promising due to their moderate effects and natural quality (Rastogi et al 2011).…”

Section: Resultsmentioning

confidence: 99%

Antibacterial activity of viable and heat‐killed probiotic strains against oral pathogens

Chen

Hsieh

et al. 2020

Lett Appl Microbiol

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Probiotics can stabilize gut flora, regulate intestinal immunity and protect the host from enteric diseases; however, their roles in oral health have received little attention compared to their roles in gut health. Nowadays, the prevalence of sugar‐sweetened foods and abuse of antibiotics contribute towards dysbiosis of oral microbiota and drug resistance development in oral pathogens, resulting in various intractable oral diseases. We screened the antibacterial activities of viable and heat‐killed probiotic strains against the oral pathogens Streptococcus mutans, Porphyromonas gingivalis, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans. The probiotic strains Lactobacillus salivarius subsp. salicinius AP‐32, L. rhamnosus CT‐53, L. paracasei ET‐66 and Bifidobacterium animalis subsp. lactis CP‐9 displayed strong antipathogenic activities, whereas heat‐killed AP‐32, CT‐53 and ET‐66 displayed high levels of pathogen inhibition. The antibacterial activities of these probiotics were not associated with their H2O2 production; L. acidophilus TYCA02 produced high levels of H2O2 but merely exhibited moderate antibacterial activities. Oral tablets containing probiotics showed positive inhibitory effects against oral pathogens, particularly those containing viable probiotics. Our results indicate that probiotics prevent the growth of oral pathogens and improve oral health, providing insights into the antipathogenic efficacy of different probiotic species and their potential role in functional foods that improve oral health. Significance and Impact of the Study Our study provides insights into the antipathogenic efficacy of different probiotic species and their potential roles in developing functional foods to improve oral health. We showed that the probiotic strains Lactobacillus salivarius subsp. salicinius AP‐32, L. rhamnosus CT‐53, L. paracasei ET‐66 and Bifidobacterium animalis subsp. lactis CP‐9 have great potential for use in the development of functional foods to improve oral health. Since active probiotics may provide strong and long‐term protection, the development of functional food products should favour the use of viable bacteria.

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Section: Resultsmentioning

confidence: 99%

Antibacterial activity of viable and heat‐killed probiotic strains against oral pathogens

Chen

Hsieh

et al. 2020

Lett Appl Microbiol

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“…g ., Lactobacillus plantarum , Lactobacillus reuteri ) 128 , facilitate the absorption like vitamins and mineral compounds, modulate immune system 129 and show efficacy in antibiotic 130 or anti-cancerogenic treatment 131 . Therefore, loads of clinical trials conducted suggesting that probiotics might assist in the prophylaxis and treatment for gastrointestinal diseases 132 , allergic diseases 133 , obesity 134 , type 2 diabetes (T2D) 135 , cancer and associated side effects 136 , and depressive symptoms 137 , etc. As they are widely used in the dietary supplements, functional food and pharmaceutical formulas, increasing attention should be paid to their potential influence on the pharmacokinetics of drugs which may be co-administered.…”

Section: The Influence Of Probiotics On the Bioavailability Of Oral Drugsmentioning

confidence: 99%

The influence of the gut microbiota on the bioavailability of oral drugs

Zhang

Han

Huang

et al. 2021

Acta Pharmaceutica Sinica B

138

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Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract. One of the critical and most overlooked factors is the symbiotic gut microbiota that can modulate the bioavailability of oral drugs by participating in the biotransformation of oral drugs, influencing the drug transport process and altering some gastrointestinal properties. In this review, we summarized the existing research investigating the possible relationship between the gut microbiota and the bioavailability of oral drugs, which may provide great ideas and useful instructions for the design of novel drug delivery systems or the achievement of personalized medicine.

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“…The application of fecal transplantation, prebiotics, and probiotics are constantly expanding. Multiple autoimmune conditions are treated by probiotics including systemic lupus erythematosus (SLE), rheumatoid arthritis, Celiac and Crohn’s diseases, ulcerative colitis, multiple sclerosis, Sjogren’s syndrome, systemic sclerosis, antiphospholipid syndrome, myasthenia gravis, diabetes type 1 [13,50,51,52,53,54,55,56,57,58,59,60,61,62]. In many local and international scientific conferences, the probiotics trial as a supplement of adjunct therapy is presented.…”

Section: Introductionmentioning

confidence: 99%

Probiotics: If It Does Not Help It Does Not Do Any Harm. Really?

Lerner

Shoenfeld

Tenbusch³

2019

Microorganisms

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Probiotics per definition should have beneficial effects on human health, and their consumption has tremendously increased in the last decades. In parallel, the amount of published material and claims for their beneficial efficacy soared continuously. Recently, multiple systemic reviews, meta-analyses, and expert opinions expressed criticism on their claimed effects and safety. The present review describes the dark side of the probiotics, in terms of problematic research design, incomplete reporting, lack of transparency, and under-reported safety. Highlighted are the potential virulent factors and the mode of action in the intestinal lumen, risking the physiological microbiome equilibrium. Finally, regulatory topics are discussed to lighten the heterogeneous guidelines applied worldwide. The shift in the scientific world towards a better understanding of the human microbiome, before consumption of the probiotic cargo, is highly endorsed. It is hoped that better knowledge will extend the probiotic repertoire, re-confirm efficacy or safety, establish their efficacy and substantiate their beneficial effects.

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Recent Advances in Probiotics as Live Biotherapeutics Against Gastrointestinal Diseases

Cited by 17 publications

References 0 publications

Antibacterial activity of viable and heat‐killed probiotic strains against oral pathogens

Antibacterial activity of viable and heat‐killed probiotic strains against oral pathogens

The influence of the gut microbiota on the bioavailability of oral drugs

Probiotics: If It Does Not Help It Does Not Do Any Harm. Really?

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