Recent advances in protein-imprinted polymers: synthesis, applications and challenges

Abstract

Molecular imprinting technique (MIT), also described as “lock to key” method, has been demonstrated as an effective tool for the creation of synthetic polymers with antibody-like sites to specifically recognize...

A Novel Hexokinases Inhibitor Based on Molecularly Imprinted Polymer for Combined Starvation and Enhanced Photothermal Therapy of Malignant Tumors

“…Molecular imprinting technology (MIT) utilizes the affinity and specificity of imprinted cavities to the template to selectively recognize and robustly adsorb target proteins. 28 Given the specific recognition ability of molecularly imprinted polymers (MIPs), a proliferation of researches have investigated the application of MIPs in cancer therapy as signal pathway inhibitors 29,30 and enzyme inhibitors 31−33 recently. Compared with small-molecule inhibitors, MIPs 34−37 have attracted considerable interest, because of their storage and chemical stability, low cost, potential reusability, and specific recognition ability.…”

“…Molecular imprinting technology (MIT) utilizes the affinity and specificity of imprinted cavities to the template to selectively recognize and robustly adsorb target proteins . Given the specific recognition ability of molecularly imprinted polymers (MIPs), a proliferation of researches have investigated the application of MIPs in cancer therapy as signal pathway inhibitors , and enzyme inhibitors − recently.…”

A multi-site recognition molecularly imprinted solid-phase microextraction fiber for selective enrichment of three cross-class environmental endocrine disruptors

“…[25][26][27] Molecularly imprinted polymers are purposely tailored polymers with specific target compounds offering good mechanical and stable chemical properties but also specific recognition sites with high affinity in their stable matrices to selectively capture the target compounds. [28][29][30][31][32] Recently, a novel SPME sample pretreatment strategy was developed for the detection of norfloxacin in the marine environment by preparing graphene oxide molecularly imprinted polymers and then loading the polymers onto molecularly imprinted solid phase microextraction columns. 33 In addition, MIP-SPME is highly sensitive and convenient for the selective and high-throughput determination of various organophosphate flame retardants at trace levels in environmental matrices.…”

Post-imprinting modification: electrochemical and scanning electrochemical microscopy studies of a semi-covalently surface imprinted polymer

“…Polymer-based synthetic receptors have been reported as alternatives to antibodies with comparable molecular recognition capabilities. [1][2][3] Following the molecular imprinting approach to synthesize such receptors has proven to be one of the most promising strategies for antibody mimicking. This approach has been used to synthesize nanostructured polymers exhibiting antibody-antigen-like affinity for template analytes such as drugs, toxins, biomarker biomolecules, and macromolecules, including proteins and peptides.…”