Recent Advances in Regioselective C–H Bond Functionalization of Free Phenols

Abstract

Phenols are important readily available synthetic building blocks and starting materials for organic synthetic transformations, which are widely found in agrochemicals, pharmaceuticals, and functional materials. The C–H functionalization of free phenols has proven to be an extremely useful tool in organic synthesis, which provides efficient increases in phenol molecular complexity. Therefore, approaches to functionalizing existing C–H bonds of free phenols have continuously attracted the attention of organic chemists. In this review, we summarize the current knowledge and recent advances in ortho-, meta-, and para-selective C–H functionalization of free phenols in the last five years.

Phenols as an alternative, neuroprotective, and preventive strategy for Alzheimer's disease: (mini-review and bibliometric analysis)

“…The phenolic compounds are widely distributed in the cell walls of plants, forming part of polymers such as p-hydroxybenzoic acid, suberin, and lignin. In the case of lignin, a cross-arrangement of phenols is observed, with diverse spatial and structural distributions, adopting ortho-, meta-and para-positions (Li et al, 2023). This structural variability is due to the susceptibility of the benzene ring in phenols to be modified by hydroxyl groups (Hithamani et al, 2022).…”