Recent advances in sampling and sample preparation for effect-directed environmental analysis

Huang, Shuyao; Fan, Mengge; Wawryk, Nicholas J.P.; Qiu, Junlang; Yang, Xin; Zhu, Fang; Ouyang, Gangfeng; Li, Xing‐Fang

doi:10.1016/j.trac.2022.116654

Cited by 18 publications

(13 citation statements)

References 142 publications

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“…A drinking water study of molecular weight fractions of DBPs also used EDA to determine whether high molecular weight DBP fractions in chlorinated and chloraminated water are toxic and to obtain information on their chemical composition (see Drinking Water and Swimming Pool Disinfection Byproducts). An excellent review article by Huang et al details recent advances in sampling and sample preparation for EDA of environmental samples, including water, sediment, and biological samples . Fractionation is key for EDA, where the individual fractions are tested for toxicity in a biological assay, and increasingly finer fractions are collected until the driver of toxicity is identified using various instruments, including high-resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR) spectroscopy, and sometimes infrared (IR) spectroscopy.…”

Section: Background and Trendsmentioning

confidence: 99%

“…An excellent review article by Huang et al details recent advances in sampling and sample preparation for EDA of environmental samples, including water, sediment, and biological samples. 2 Fractionation is key for EDA, where the individual fractions are tested for toxicity in a biological assay, and increasingly finer fractions are collected until the driver of toxicity is identified using various instruments, including high-resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR) spectroscopy, and sometimes infrared (IR) spectroscopy. New EDA workflows are being developed to shorten analysis time and increase resolution and throughput.…”

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confidence: 99%

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Water Analysis: Emerging Contaminants and Current Issues

Richardson,

Manasfi

2024

Anal. Chem.

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BACKGROUND AND TRENDSThis biennial review covers developments in water analysis for emerging environmental contaminants mainly over the period of September 2021−December 2023 (with a few in early 2024). Analytical Chemistry's policy is to limit reviews to a maximum of ∼250 significant references and to mainly focus on new trends. Therefore, only a small fraction of the quality research publications are discussed. The previous Water Analysis review (with Thomas Ternes) was published in 2022. 1 This year, Tarek Manasfi joined to cover the section on pharmaceuticals and hormones. We welcome any comments you have on this Review

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Section: Background and Trendsmentioning

confidence: 99%

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confidence: 99%

Water Analysis: Emerging Contaminants and Current Issues

Richardson,

Manasfi

2024

Anal. Chem.

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“…HPTLC is currently the preferred method for chemical risk assessment in a survey and routine monitoring of surface waters employing SPE as the concentration step. Extracts are typically separated without further clean‐up [3, 4, 95]. The detection of anticipated as well as unknown compounds and their metabolites at low concentrations is typically performed by their specific biological responses.…”

Section: Solid‐phase Extractionmentioning

confidence: 99%

Sample preparation for planar chromatography

Poole

2023

J of Separation Science

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High‐performance thin‐layer chromatography has favorable properties for high‐throughput separations with a high matrix tolerance. Sample preparation, however, is sometimes required to control specific matrix interferences and to enhance the detectability of target compounds. Trends in contemporary applications have shifted from absorbance and fluorescence detection to methods employing bioassays and mass spectrometry. Traditional methods (shake‐flask, heat at reflux, Soxhlet, and hydrodistillation) are being challenged by automated instrumental approaches (ultrasound‐assisted and microwave‐assisted solvent extraction, pressurized liquid extraction, and supercritical fluid extraction) and the quick, easy cheap, efficient, rugged, and safe extraction method for faster and streamlined sample processing. Liquid‐liquid extraction remains the most widely used approach for sample clean‐up with increasing competition from solid‐phase extraction. On‐layer sample, clean‐up by planar solid‐phase extraction is increasingly used for complex samples and in combination with heart‐cut multimodal systems. The automated spray‐on sample applicator, the elution head interface, biological detection of target and non‐target compounds, and straightforward mass spectrometric detection are highlighted as the main factors directing current interest toward faster and simpler sample workflows, analysis of more complex samples, and the determination of minor contaminants requiring high concentration factors.

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“…The evaluation of unknown hazardous TPs during water chlorination is complicated because reference standards for these TPs are not available. Effect-directed analysis (EDA) can be applied to reduce this complexity and identify the main hazardous chemicals in complex mixtures by fractionation, bioassays, and chemical analysis. − To date, EDA has been widely used to identify toxicants in natural products and environmental samples, but it has rarely been used to evaluate the unknown hazardous TPs generated during water chlorination. ,− Furthermore, in most cases, the feasibility of EDA is limited by the bioassay and not by chemical analysis . The selection and application of bioassays, which play a central role in EDA, must consider specific aspects of this approach .…”

Section: Introductionmentioning

confidence: 99%

Toxicity Evaluation and Effect-Based Identification of Chlorine Disinfection Products of the Anti-COVID-19 Drug Chloroquine Phosphate

Fang

Zhao

et al. 2023

Environ. Sci. Technol.

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Antiviral transformation products (TPs) generated during wastewater treatment are an environmental concern, as their discharge, in considerable amounts, into natural waters during a pandemic can pose possible risks to the aquatic environment. Identification of the hazardous TPs generated from antivirals during wastewater treatment is important. Herein, chloroquine phosphate (CQP), which was widely used during the coronavirus disease-19 (COVID-19) pandemic, was selected for research. We investigated the TPs generated from CQP during water chlorination. Zebrafish (Danio rerio) embryos were used to assess the developmental toxicity of CQP after water chlorination, and hazardous TPs were estimated using effect-directed analysis (EDA). Principal component analysis revealed that the developmental toxicity induced by chlorinated samples could be relevant to the formation of some halogenated TPs. Fractionation of the hazardous chlorinated sample, along with the bioassay and chemical analysis, identified halogenated TP387 as the main hazardous TP contributing to the developmental toxicity induced by chlorinated samples. TP387 could also be formed in real wastewater during chlorination in environmentally relevant conditions. This study provides a scientific basis for the further assessment of environmental risks of CQP after water chlorination and describes a method for identifying unknown hazardous TPs generated from pharmaceuticals during wastewater treatment.

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Recent advances in sampling and sample preparation for effect-directed environmental analysis

Cited by 18 publications

References 142 publications

Water Analysis: Emerging Contaminants and Current Issues

Water Analysis: Emerging Contaminants and Current Issues

Sample preparation for planar chromatography

Toxicity Evaluation and Effect-Based Identification of Chlorine Disinfection Products of the Anti-COVID-19 Drug Chloroquine Phosphate

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