Recent Advances in Silver Nanoparticles Containing Nanofibers for Chronic Wound Management

Abstract

Infections are the primary cause of death from burns and diabetic wounds. The clinical difficulty of treating wound infections with conventional antibiotics has progressively increased and reached a critical level, necessitating a paradigm change for enhanced chronic wound care. The most prevalent bacterium linked with these infections is Staphylococcus aureus, and the advent of community-associated methicillin-resistant Staphylococcus aureus has posed a substantial therapeutic challenge. Most existing wound dressings are ineffective and suffer from constraints such as insufficient antibacterial activity, toxicity, failure to supply enough moisture to the wound, and poor mechanical performance. Using ineffective wound dressings might prolong the healing process of a wound. To meet this requirement, nanoscale scaffolds with their desirable qualities, which include the potential to distribute bioactive agents, a large surface area, enhanced mechanical capabilities, the ability to imitate the extracellular matrix (ECM), and high porosity, have attracted considerable interest. The incorporation of nanoparticles into nanofiber scaffolds constitutes a novel approach to “nanoparticle dressing” that has acquired significant popularity for wound healing. Due to their remarkable antibacterial capabilities, silver nanoparticles are attractive materials for wound healing. This review focuses on the therapeutic applications of nanofiber wound dressings containing Ag-NPs and their potential to revolutionize wound healing.

Nanomaterials in the Wound Healing Process: New Insights and Advancements

“…Healing a wound requires a series of coordinated events, including clotting, inflammation, tissue deposition, fibroplasia, differentiation of the extracellular matrix, cellular contraction, tissue remodeling, and, finally, epithelialization. In order to combat bacterial growth in long-standing wounds and burns, doctors frequently turn to silver compounds like silver nitrate as well as silver sulfadiazine [ 145 , 146 ]. The faster healing of wounds caused by diabetes is achieved with the use of AgNPs, which promote the differentiation of fibroblasts into myofibroblasts.…”

Nanofibrous Scaffolds for Diabetic Wound Healing

“…Unlike other antibiotics, it prevents the development of bacterial resistance. Silver nanoparticles can also be combined with antibiotics such as sulphanilamide for synergistic antibacterial (against a wide range of both Gram-positive and Gram-negative bacteria) and wound healing effects [ 92 , 93 , 94 ]. Other than silver nanoparticles, there are several metal ions (e.g., iron, zinc, titanium, gold, copper, etc.)…”

Advances in electrospun chitosan nanofiber biomaterials for biomedical applications

“…Scaffolds within the nanoscale range have garnered significant interest due to their appealing characteristics, such as their ability to transport bioactive agents, elevated surface area, enhanced mechanical properties, emulation of the extracellular matrix, and substantial porosity. 133 Chitosan nanofibrous materials have the potential to be encapsulated or loaded with metal-based nanoparticles, which can augment their therapeutic efficacy in wound healing applications. Metal-based nanoparticles, specifically silver nanoparticles, have been extensively researched and have demonstrated favorable characteristics, including exceptional antibacterial activity, antioxidant and anti-inflammatory properties, and promotion of cell growth.…”