Recent advances in stereocomplexation of enantiomeric PLA-based copolymers and applications

Liu, Yupeng; Tan, B. T. G.; Lin, Tingting; He, Chaobin

doi:10.1016/j.progpolymsci.2016.05.003

Cited by 245 publications

(159 citation statements)

References 179 publications

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“…Polymer, in general, has been one of the go‐to classes of materials to be used as controlled drug delivery vehicles due to its myriad of properties including biocompatibility, the ability to functionalize, and ease of synthesis . With newer polymerization techniques developed over the years, we now have improved control over the structures of synthesized macromolecules, especially those of the star‐shaped polymers, which has allowed us to functionalize and recombine various arm architectures to suit various needs .…”

Section: Introductionmentioning

confidence: 99%

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Yang

Deen

et al. 2017

Macromol. Rapid Commun.

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125

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With the advancement of polymer engineering, complex star-shaped polymer architectures can be synthesized with ease, bringing about a host of unique properties and applications. The polymer arms can be functionalized with different chemical groups to fine-tune the response behavior or be endowed with targeting ligands or stimuli responsive moieties to control its physicochemical behavior and self-organization in solution. Rheological properties of these solutions can be modulated, which also facilitates the control of the diffusion of the drug from these star-based nanocarriers. However, these star-shaped polymers designed for drug delivery are still in a very early stage of development. Due to the sheer diversity of macromolecules that can take on the star architectures and the various combinations of functional groups that can be cross-linked together, there remain many structure-property relationships which have yet to be fully established. This review aims to provide an introductory perspective on the basic synthetic methods of star-shaped polymers, the properties which can be controlled by the unique architecture, and also recent advances in drug delivery applications related to these star candidates.

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Section: Introductionmentioning

confidence: 99%

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Yang

Deen

et al. 2017

Macromol. Rapid Commun.

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125

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“…Therefore, research of SCs of PLLA/poly( d ‐lactic acid) (PDLA) has attracted much attention . Li and co‐workers published excellent review articles on the recent progress in utilizing SC formation strategy to enhance the thermal and mechanical properties of PLA. Chen and co‐workers have devoted themselves to the research of PLA and SCs for many years .…”

Section: Introductionmentioning

confidence: 99%

Relationship between the crystallization behavior of poly(ethylene glycol) and stereocomplex crystallization of poly(L‐lactic acid)/poly(D‐lactic acid)

Luo

Yang

Xiao

et al. 2018

Polymer International

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Poly(l‐lactic acid) (PLLA) is a good biomedical polymer material with wide applications. The addition of poly(ethylene glycol) (PEG) as a plasticizer and the formation of stereocomplex crystals (SCs) have been proved to be effective methods for improving the crystallization of PLLA, which will promote its heat resistance. In this work, the crystallization behavior of PEG and PLLA/poly(d‐lactic acid) (PDLA) in PLLA/PDLA/PEG and PEG‐b‐PLLA/PEG‐b‐PDLA blends has been investigated using differential scanning calorimetry, polarized optical microscopy and X‐ray diffraction. Both SCs and homocrystals (HCs) were observed in blends with asymmetric mass ratio of PLLA/PDLA, while exclusively SCs were observed in blends with approximately equal mass ratio of PLLA/PDLA. The crystallization of PEG was only observed for the symmetric blends of PLLA39k/PDLA35k/PEG2k, PLLA39k/PDLA35k/PEG5k, PLLA69k/PDLA96k/PEG5k and PEG‐b‐PLLA31k/PEG‐b‐PDLA27k, where the mass ratio of PLLA/PDLA was approximately 1/1. The results demonstrated that the formation of exclusively SCs would facilitate the crystallization of PEG, while the existence of both HCs and SCs could restrict the crystallization of PEG. The crystallization of PEG is related to the crystallinity of PLLA and PDLA, which will be promoted by the formation of SCs. © 2017 Society of Chemical Industry

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“…PLA is biodegradable polyester (Figure ) which could be used to develop composites with PHB. PLA has brittle nature and its T g is 50–60°C, which makes it an excellent material to develop biocomposites with enhanced mechanical properties . Aluthge and coworkers reported the synthesis of copolymers containing PHB and PLA.…”

Section: Phb Based Biocompositesmentioning

confidence: 99%

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

Raza

Noor

Khalil

2019

Biotechnology Progress

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Poly(hydroxybutyrate) (PHB) has become an attractive biomaterial in research and development for past few years. It is natural bio‐based aliphatic polyester produced by many types of bacteria. Due to its biodegradable, biocompatible, and eco‐friendly nature, PHB can be used in line with bioactive species. However, high production cost, thermal instability, and poor mechanical properties limit its desirable applications. So there is need to incorporate PHB with other materials or biopolymers for the development of some novel PHB based biocomposites for value addition. Many attempts have been employed to incorporate PHB with other biomaterials (or biopolymers) to develop sustainable biocomposites. In this review, some recent developments in the synthesis of PHB based biocomposites and their biomedical, packaging and tissue engineering applications have been focused. The development of biodegradable PHB based biocomposites with improved mechanical properties could be used to overcome its native limitations hence to open new possibilities for industrial applications.

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Recent advances in stereocomplexation of enantiomeric PLA-based copolymers and applications

Cited by 245 publications

References 179 publications

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Relationship between the crystallization behavior of poly(ethylene glycol) and stereocomplex crystallization of poly(L‐lactic acid)/poly(D‐lactic acid)

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

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