Recent advances in strategies to target the behavior of macrophages in wound healing

Zheng, Hongkun; Cheng, Xinwei; Lu, Jinhua; Shan, Shengzhou; Yang, Jing; Zhou, Jia

doi:10.1016/j.biopha.2023.115199

Cited by 16 publications

(5 citation statements)

References 158 publications

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“…Our earlier publications emphasized the role of mature macrophages in diabetic wound healing (12,24), without distinguishing between M1 and M2. CD163 + M2 macrophages contribute significantly to wound healing by promoting anti-inflammatory responses and releasing IL-10 and IL-35 (40). Thus, we used the CD163 biomarker to explore mechanisms of diabetic wound healing.…”

Section: Discussionmentioning

confidence: 99%

CD64 plays a key role in diabetic wound healing

Zhang,

Yuan,

Tan

et al. 2024

Front. Immunol.

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IntroductionWound healing poses a clinical challenge in diabetes mellitus (DM) due to compromised host immunity. CD64, an IgG-binding Fcgr1 receptor, acts as a pro-inflammatory mediator. While its presence has been identified in various inflammatory diseases, its specific role in wound healing, especially in DM, remains unclear.ObjectivesWe aimed to investigate the involvement of CD64 in diabetic wound healing using a DM animal model with CD64 KO mice.MethodsFirst, we compared CD64 expression in chronic skin ulcers from human DM and non-DM skin. Then, we monitored wound healing in a DM mouse model over 10 days, with or without CD64 KO, using macroscopic and microscopic observations, as well as immunohistochemistry.ResultsCD64 expression was significantly upregulated (1.25-fold) in chronic ulcerative skin from DM patients compared to non-DM individuals. Clinical observations were consistent with animal model findings, showing a significant delay in wound healing, particularly by day 7, in CD64 KO mice compared to WT mice. Additionally, infiltrating CD163+ M2 macrophages in the wounds of DM mice decreased significantly compared to non-DM mice over time. Delayed wound healing in DM CD64 KO mice correlated with the presence of inflammatory mediators.ConclusionCD64 seems to play a crucial role in wound healing, especially in DM conditions, where it is associated with CD163+ M2 macrophage infiltration. These data suggest that CD64 relies on host immunity during the wound healing process. Such data may provide useful information for both basic scientists and clinicians to deal with diabetic chronic wound healing.

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Section: Discussionmentioning

confidence: 99%

CD64 plays a key role in diabetic wound healing

Zhang,

Yuan,

Tan

et al. 2024

Front. Immunol.

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“…Precise control of cellular behavior is crucial to ensuring rapid and complete repair of skin wounds. [112][113][114] In recent years, with the rapid development of molecular biology and cell biology, researchers have gained a deeper understanding in regulating cellular behavior. By intervening in the function of membrane proteins and downstream signaling pathways, cell proliferation, migration, and differentiation can be effectively regulated, thereby accelerating the wound healing process.…”

Section: Magneto-responsive Biocomposites For Regulating Cell Behaviormentioning

confidence: 99%

Magneto-responsive biocomposites in wound healing: from characteristics to functions

Ding,

Hao,

Mao

2024

J. Mater. Chem. B

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“…M1 macrophages engage in the phagocytosis of pathogens and cellular debris, secrete pro-inflammatory factors, and contribute to the inflammatory phase of wound healing [ 21 ]. Conversely, M2 macrophages predominantly participate in the proliferation and remodelling phases, actively contributing to granulation tissue formation, remodeling processes, and the resolution of inflammation [ 22 ]. It is crucial to note that sustained activation of M1 macrophages can result in chronic inflammation, leading to delayed wound healing.…”

Section: Introductionmentioning

confidence: 99%

Understanding Fibrous Tissue in the Effective Healing of Rotator Cuff Injury

Rajalekshmi,

K. Agrawal

2024

J Surg Res

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The rotator cuff is a crucial group of muscles and tendons in the shoulder complex that plays a significant role in the stabilization of the glenohumeral joint and enabling a wide range of motion. Rotator cuff tendon tears can occur due to sudden injuries or degenerative processes that develop gradually over time, whether they are partial or full thickness. These injuries are common causes of shoulder pain and functional impairment, and their complex nature highlights the essential role of the rotator cuff in shoulder function. Scar formation is a crucial aspect of the healing process initiated following a rotator cuff tendon tear, but excessive fibrous tissue development can potentially lead to stiffness, discomfort, and movement limitations. Age is a critical risk factor, with the prevalence of these tears increasing among older individuals. This comprehensive review aims to delve deeper into the anatomy and injury mechanisms of the rotator cuff. Furthermore, it will inspect the signaling pathways involved in fibrous tissue development, evaluate the various factors affecting the healing environment, and discuss proactive measures aimed at reducing excessive fibrous tissue formation. Lastly, this review identifed gaps within existing knowledge to advance methods for better management of rotator cuff tendon injuries.

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Recent advances in strategies to target the behavior of macrophages in wound healing

Cited by 16 publications

References 158 publications

CD64 plays a key role in diabetic wound healing

CD64 plays a key role in diabetic wound healing

Magneto-responsive biocomposites in wound healing: from characteristics to functions

Understanding Fibrous Tissue in the Effective Healing of Rotator Cuff Injury

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