Recent Advances in Surface Plasmon Resonance Microscopy

Huang, Songfeng; Chen, Jiajie; Zhang, Teliang; Dai, Xiaoqi; Wang, Xueliang; Zhou, Jianxing; Kong, Weifu; Liu, Qian; Qu, Junle; Shao, Yufeng

doi:10.3390/chemosensors10120509

Cited by 8 publications

(2 citation statements)

References 61 publications

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“…Spatial resolution is vitally important for molecular imaging. While some reviews have been published targeting working principles, setups, and applications [55,[93][94][95][96][97][98], they lack a focus on the increment of spatial resolution. In this minireview, we will start with an overview of the principles and instrumentation of an imaging methodology based on SPR.…”

Section: Introductionmentioning

confidence: 99%

Surface Plasmon Resonance Biosensors: A Review of Molecular Imaging with High Spatial Resolution

Xu,

Zhang,

Chen

2024

Biosensors

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Surface plasmon resonance (SPR) is a powerful tool for determining molecular interactions quantitatively. SPR imaging (SPRi) further improves the throughput of SPR technology and provides the spatially resolved capability for observing the molecular interaction dynamics in detail. SPRi is becoming more and more popular in biological and chemical sensing and imaging. However, SPRi suffers from low spatial resolution due to the imperfect optical components and delocalized features of propagating surface plasmonic waves along the surface. Diverse kinds of approaches have been developed to improve the spatial resolution of SPRi, which have enormously impelled the development of the methodology and further extended its possible applications. In this minireview, we introduce the mechanisms for building a high-spatial-resolution SPRi system and present its experimental schemes from prism-coupled SPRi and SPR microscopy (SPRM) to surface plasmonic scattering microscopy (SPSM); summarize its exciting applications, including molecular interaction analysis, molecular imaging and profiling, tracking of single entities, and analysis of single cells; and discuss its challenges in recent decade as well as the promising future.

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Section: Introductionmentioning

confidence: 99%

Surface Plasmon Resonance Biosensors: A Review of Molecular Imaging with High Spatial Resolution

Xu,

Zhang,

Chen

2024

Biosensors

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“…Surface plasmon resonance phenomenon is used widely in many applications because it does not require a label of the molecules, and any molecule can be detected. The technique is used as a high-sensitivity plasmonic biosensor capable of simple and fast label-free detection of diseases and many more [7]. The sensitivity detection of the SPR biosensor depends on a range of parameters which include the refractive index of the sample being investigated, angle of incidence of light, and wavelength of the probe light from the light source.…”

Section: Introductionmentioning

confidence: 99%

Enhancing limit of detection in surface plasmon resonance biosensors: a sensitivity analysis for optimal performance

Sekhwama,

Mpofu,

Sivarasu

et al. 2024

Optical Interactions With Tissue and Cells XXXV

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Surface plasmon resonance (SPR) is an optical phenomenon used for detecting various biological substances and disease diagnostics due to its high sensitivity. SPR-based biosensors are highly sensitive optical devices and rapid detection devices, and they also have the added advantage of being label-free biosensors. Sensitivity and limit of detection are critical parameters in studying the performance of any biosensor. In plasmonic biosensors, the sensitivity and limit of detection are dependent on several parameters and a sensitivity analysis is critical to determine these parameters which can optimize our biosensor performance. Sensitivity analyses of SPR-based biosensors are important for enhancing the limit of detection (LoD), comparing performance, optimizing biosensor design, ensuring quality control, and advancing biosensing technology. In this study, we theoretically perform a sensitivity analysis on an SPR-based biosensor and consider different ways to enhance the LoD of the biosensor. The interaction we study is that of different proteins binding to gold (Au) surfaces via an electrostatic mechanism. In this study, we vary a wide range of parameters ranging from metal film thickness, and wavelengths of light incident on the biosensor and show how these parameters can be used to optimize our plasmonic biosensor in terms of sensitivity and LoD. The development of optimal biosensors is ever more critical, particularly considering recurring pandemics and disease outbreaks. Good sensitivity analysis can lead to high quality and highly effective biosensors which can be useful in the fight against disease outbreaks and pandemics.

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Development of surface plasmon resonance sensor with enhanced sensitivity for low refractive index detection

Patel,

Wekalao,

Alsalman

et al. 2023

Opt Quant Electron

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Recent Advances in Surface Plasmon Resonance Microscopy

Cited by 8 publications

References 61 publications

Surface Plasmon Resonance Biosensors: A Review of Molecular Imaging with High Spatial Resolution

Surface Plasmon Resonance Biosensors: A Review of Molecular Imaging with High Spatial Resolution

Enhancing limit of detection in surface plasmon resonance biosensors: a sensitivity analysis for optimal performance

Development of surface plasmon resonance sensor with enhanced sensitivity for low refractive index detection

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