Recent advances in synthesis, metal complexes and biological evaluation of 2-aryl, 2-pyridyl and 2-pyrimidylbenzothiazoles as potential chemotherapeutics

Crystal structure of 3-(benzo[d]thiazol-2-yl)-6-methyl-2H-chromen-2-one

“…Benzothiazole and its derivatives are important heterocyclic aromatic compounds. Benzothiazole can be readily substituted at the C-2 position of the thiazole ring (Elgemeie et al, 2020). Compounds containing a benzothiazolyl group have found numerous applications in medicine and in nonlinear optics (Sigmundova ´et al, 2007).…”

Squaraine-Based Optical Sensors: Designer Toolbox for Exploring Ionic and Molecular Recognitions

“…N-containing heterocycles, in particular, pyridine, are among the most commonly used moieties that are present in a variety of binding motifs for transition and heavy metal ions [87][88][89][90]. The incorporation of such pyridine-containing chelators, such as di-2pyridylmethylamine (i.e., dipicolylamine), in various dye scaffolds is a proven strategy to obtain viable chemosensors [91][92][93].…”

Crystal structure of N′-[2-(benzo[d]thiazol-2-yl)acetyl]benzohydrazide, an achiral compound crystallizing in space group P1 with Z = 1

“…One of the most prominent heterocycles is benzothiazole, a privileged scaffold in the field of synthetic and medicinal chemistry (Elgemeie et al, 2000a,b). Its derivatives and metal complexes possess a wide range of pharmacological properties and a high degree of structural diversity that have proved vital for the investigation for novel therapeutics (Elgemeie et al, 2020;Gill et al, 2015). The carbon atom C2 (standard numbering; the carbon atom between nitrogen and sulfur) is the most attractive site both from a synthetic and medicinal point of view (Azzam et al, 2020a,b).…”