Recent advances in targeted fungicides and immune elicitors for rice blast management

Shi, Huanbin; Naqvi, Naweed I.; Kou, Yanjun

doi:10.1016/j.xplc.2024.101032

Plant Communications

2024

DOI: 10.1016/j.xplc.2024.101032

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Recent advances in targeted fungicides and immune elicitors for rice blast management

Huanbin Shi,

Naweed I. Naqvi,

Yanjun Kou

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2024

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Cited by 2 publications

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Combinatorial Targeting of Common Docking and ATP Binding Sites on Mps1 MAPK for Management of Pathogenic Fungi

Kong,

Li,

et al. 2024

J. Agric. Food Chem.

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Resistance in pathogenic fungi necessitates the development of fungicides with new mechanisms of action. The Mps1 MAPK of Magnaporthe oryzae, the pathogen of rice blast disease, has been shown to be a molecular target for fungicide research. Here, we present compound TAK-733 that interacts with the common docking (CD) site of Mps1 and can be used in combination with ATP-competitive inhibitors. We initially identified compounds PLX-4720 and TAK-733 that interact with Mps1. Subsequent assays show that PLX-4720 is an ATP-competitive inhibitor, whereas TAK-733 binds to the CD site of Mps1�an interaction site for its MAPKK�but not to the ATP-binding pocket as it does in the kinase MEK1. In vivo assays demonstrated that TAK-733 exhibits combinational effects with ATP-competitive inhibitors PLX-4720 and A378−0. Collectively, we present TAK-733 as having a new mechanism of action suitable for combinational application with ATP-competitive inhibitors in the management of pathogenic fungi.

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Combinatorial Targeting of Common Docking and ATP Binding Sites on Mps1 MAPK for Management of Pathogenic Fungi

Kong,

Li,

et al. 2024

J. Agric. Food Chem.

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A glance at structural biology in advancing rice blast fungus research

Yan,

Li,

Bao

et al. 2024

Virulence

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Recent advances in targeted fungicides and immune elicitors for rice blast management

Cited by 2 publications

References 9 publications

Combinatorial Targeting of Common Docking and ATP Binding Sites on Mps1 MAPK for Management of Pathogenic Fungi

Combinatorial Targeting of Common Docking and ATP Binding Sites on Mps1 MAPK for Management of Pathogenic Fungi

A glance at structural biology in advancing rice blast fungus research

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