Recent Advances in the Antioxidant Therapies for Alzheimer’s Disease: Emphasis on Natural Antioxidants

Singh, Namrata; Ghosh, Kallol K.

doi:10.1007/978-981-13-0944-1_22

Cited by 10 publications

(6 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antioxidants have proven beneficial effects on health. There are many studies confirming their ability to prevent diseases, including cancer, neurodegenerative, autoimmune, or cardiovascular diseases [31][32][33][34]. Among different secondary plant metabolites, phenolics and flavonoids are the main compounds with considerable antioxidant activity [35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial and Antioxidant Properties of Four Lycopus Taxa and an Interaction Study of Their Major Compounds

et al. 2020

View full text Add to dashboard Cite

The compositions of leaf infusions of three genotypes of Lycopus europaeus L. with origins in central Europe, namely L. europaeus A (LeuA), L. europaeus B (LeuB), and L. europaeus C (LeuC), and one genotype of L. exaltatus (Lex), were examined by LC-MS-DAD (Liquid Chromatography Mass Spectrometry and Diode Array Detection) analysis. This revealed the presence of thirteen compounds belonging to the groups of phenolic acids and flavonoids, with a predominance of rosmarinic acid (RA) and luteolin-7-O-glucuronide (LGlr). The antimicrobial activity of leaf infusions was tested on the collection strains of Gram-positive and Gram-negative bacteria, and on the clinical Staphylococcus aureus strains. We detected higher activity against Gram-positive bacteria, of which the most susceptible strains were those of Staphylococcus aureus, including methicillin-resistant and poly-resistant strains. Furthermore, we examined the antioxidant activity of leaf infusions using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) methods, and on NIH/3T3 cell lines using dichlorodihydrofluorescein diacetate (DCFH-DA). We also studied the mutual interactions between selected infusions, namely RA and/or LGlr. In the mixtures of leaf infusion and RA or LGlr, we observed slight synergism and a high dose reduction index in most cases. This leads to the beneficial dose reduction at a given antioxidant effect level in mixtures compared to the doses of the parts used alone. Therefore, our study draws attention to further applications of the Lycopus leaves as a valuable alternative source of natural antioxidants and as a promising topical antibacterial agent for medicinal use.

show abstract

Section: Discussionmentioning

confidence: 99%

Antimicrobial and Antioxidant Properties of Four Lycopus Taxa and an Interaction Study of Their Major Compounds

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Understanding the important role the mitochondrial factor plays in the etiopathogenetic cascade of Alzheimer's disease [13], new therapeutic strategies aim at protecting the mitochondria [149] and preventing oxidative stress, calcium imbalance and eventual apoptosis might be beneficial in the treatment of early cases of AD.…”

Section: Discussionmentioning

confidence: 99%

Mitochondria and Alzheimer’s Disease: An Electron Microscopy Study

Baloyannis¹

2019

Redirecting Alzheimer Strategy - Tracing Memory Loss to Self Pathology

View full text Add to dashboard Cite

Alzheimer's disease is a progressive, irreversible presenile or senile neurodegenerative disorder, implicating mainly the mental faculties, characterized by decline of memory and judgment, learning impairment, loss of professional skills and verbal capacities, alterations of social behavior, decline of motor skills and eventual disarrangement of the autonomic equilibrium. Among the pathogenetic factors, oxidative stress and mitochondrial dysfunction may play an essential role. Alterations of mitochondria may enhance amyloid toxicity, which in turn may aggravate mitochondrial dysfunction. We describe ultrastructural alterations of mitochondria in the soma of neurons, in axons, dendritic profiles and synaptic terminals, in astrocytes in early cases of Alzheimer's disease on various areas of the cerebral and the cerebellar cortex, the hippocampus, the hypothalamus, the mammillary bodies and the medial geniculate body. The morphological and morphometric study of the mitochondria revealed an impressive polymorphism at any area of the brain. The mitochondria demonstrated variation of size and shape, fragmentation of the cristae and marked changes of their structure. The most dramatic mitochondrial alterations were observed in dendritic profiles, spines and synaptic terminals. A substantial number of astrocytes demonstrated mitochondrial alterations, which coexisted with fragmentation of Golgi apparatus and dilatation of the cisternae of the smooth endoplasmic reticulum. On the basis of our observations, we feel that therapeutic strategies aiming at protecting the mitochondria might be beneficial in the treatment of early cases of AD.

show abstract

“…Human cells remove the ROS through their defense system by the mode of enzymatic and non-enzymatic pathways. When a body contains free reactive oxygen species (ROS) beyond its defensive capacity, the ROS can start damaging fatty tissue, nucleic acids, and proteins, which can give rise to a vast sum of diseases over time, including neurological disorders [83,84], diabetes [85], cancer [86], and dermal diseases [87].…”

Section: Biological Activities Of Eckolmentioning

confidence: 99%

Characterizing Eckol as a Therapeutic Aid: A Systematic Review

et al. 2019

View full text Add to dashboard Cite

The marine biosphere is a treasure trove of natural bioactive secondary metabolites and the richest source of structurally diverse and unique compounds, such as phlorotannins and halo-compounds, with high therapeutic potential. Eckol is a precursor compound representing the dibenzo-1,4-dioxin class of phlorotannins abundant in the Ecklonia species, which are marine brown algae having a ubiquitous distribution. In search of compounds having biological activity from macro algae during the past three decades, this particular compound has attracted massive attention for its multiple therapeutic properties and health benefits. Although several varieties of marine algae, seaweed, and phlorotannins have already been well scrutinized, eckol deserves a place of its own because of the therapeutic properties it possesses. The relevant information about this particular compound has not yet been collected in one place; therefore, this review focuses on its biological applications, including its potential health benefits and possible applications to restrain diseases leading to good health. The facts compiled in this review could contribute to novel insights into the functions of eckol and potentially enable its use in different uninvestigated fields.

show abstract

Recent Advances in the Antioxidant Therapies for Alzheimer’s Disease: Emphasis on Natural Antioxidants

Cited by 10 publications

References 69 publications

Antimicrobial and Antioxidant Properties of Four Lycopus Taxa and an Interaction Study of Their Major Compounds

Antimicrobial and Antioxidant Properties of Four Lycopus Taxa and an Interaction Study of Their Major Compounds

Mitochondria and Alzheimer’s Disease: An Electron Microscopy Study

Characterizing Eckol as a Therapeutic Aid: A Systematic Review

Contact Info

Product

Resources

About