Recent advances in the application of deep eutectic solvents for the synthesis of Spiro heterocyclic scaffolds via multicomponent reactions

Javahershenas, Ramin

doi:10.1016/j.molliq.2023.122398

Cited by 20 publications

(8 citation statements)

References 63 publications

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“…[36] As cyclopropane analogs have diverse applications in bioorganic, medicinal, and pharmaceutical chemistry, an electrochemical reaction was developed for efficient and clean synthetic spirocyclopropane (8) (Scheme 4). A highly effective and easy-to-use method has been presented for synthesizing spirocyclopropanes (8) selectively with electrons by reacting indan-1,3-dione (7) with aromatic aldehydes (1) as a renewable, inexpensive, and readily available reagent. A mixture of propanol and sodium bromide was electrochemically synthesized at room temperature using constant current electrolysis.…”

Section: Spiro Compounds 21 Spirocyclopropanesmentioning

confidence: 99%

“…[4][5][6] Electrochemical multicomponent reactions can be used as a sustainable tool to synthesize, develop and study novel heterocycle scaffolds. [7][8][9][10][11][12] With continued progress and development, electro-organic heterocycle synthesis has the potential to revolutionize heterocyclic chemistry. This review describes recent progresses (from 2015 to 2023) made in the synthesis of heterocyclic frameworks using multi-component electro-organic reactions.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Multicomponent Electro‐Organic (Electrochemical) Synthesis of Heterocycles

2023

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In terms of pharmaceuticals and biological applications, synthesis of complex organic molecules is a significant and fast‐developing area. In this context, organic electrosynthesis is an alternative way to the traditional methods for chemo‐, regio‐, and stereoselective syntheses. Electro‐organic reactions occur at room temperature and normal pressure, through transferring electrons. It has been found that electrosynthesis is a mild approach for preparing electrophilic substrates, bases, and nucleophiles in situ, from highly stable and low‐level reagents; which can be further applied to make heterocycles more accessible. While several promising methods exist, multi‐component reactions (MCRs) have drawn much attention both in academia and industry worldwide, since they are cost‐efficient and environmentally friendly. Combining the electrosynthesis and MCRs has produced a great strategy in the field of organic synthesis for industry and research. This review focuses on recent advances in the electrochemical synthesis of heterocyclic compounds via multi‐component reactions, reported between 2015 and March 2023.

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Section: Spiro Compounds 21 Spirocyclopropanesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances in Multicomponent Electro‐Organic (Electrochemical) Synthesis of Heterocycles

2023

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“…In recent years, DESs have shown enormous potential for various applications thanks to their ability to solubilize compounds otherwise not soluble in classical organic solvents [20], such as separation and extraction processes [21][22][23][24], synthesis [25][26][27][28], biocatalysis [29,30], CO 2 capture [31][32][33], drug delivery [34][35][36], to mention just a few recent reviews.…”

Section: Introductionmentioning

confidence: 99%

Natural Deep Eutectic Solvents as Rust Removal Agents from Lithic and Cellulosic Substrates

Gabriele,

Casieri,

Spreti

2024

Molecules

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The peculiar physicochemical features of deep eutectic solvents (DESs), in particular their tunability, make them ideal media for various applications. Despite their ability to solubilize metal oxides, their use as rust removers from valuable substrates has not yet been thoroughly investigated. In this study, we chose three known DESs, consisting of choline chloride and acetic, oxalic or citric acid for evaluating their ability to remove corrosion products from a cellulose-based material as linen fabric and two different lithotypes, as travertine and granite. The artificial staining was achieved by placing a rusty iron grid on their surfaces. The DESs were applied by means of cellulose poultice on the linen fabrics, while on the rusted stone surfaces with a cotton swab. Macro- and microscopic observations, colorimetry and SEM/EDS analysis were employed to ascertain the cleaning effectiveness and the absence of side effects on the samples after treatment. Oxalic acid-based DES was capable of removing rust stains from both stone and cellulose-based samples, while choline chloride/citric acid DES was effective only on stone specimens. The results suggest a new practical application of DESs for the elimination of rust from lithic and cellulosic substrates of precious and artistic value.

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“…In this review, we reviewed recent progress in the multicomponent reactions [28] , [29] , [30] , [31] , [32] and summarize recent advances in the multicomponent sonochemical synthesis of heterocycles using malononitrile as a pivotal component. Because these heterocycles are applied to biology and pharmaceuticals, the mechanism of reaction, the scope and limitations of these transformations will be discussed.…”

Section: Introductionmentioning

confidence: 99%

Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles

Javahershenas,

Nikzat

2024

Ultrasonics Sonochemistry

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Recent advances in the application of deep eutectic solvents for the synthesis of Spiro heterocyclic scaffolds via multicomponent reactions

Cited by 20 publications

References 63 publications

Recent Advances in Multicomponent Electro‐Organic (Electrochemical) Synthesis of Heterocycles

Recent Advances in Multicomponent Electro‐Organic (Electrochemical) Synthesis of Heterocycles

Natural Deep Eutectic Solvents as Rust Removal Agents from Lithic and Cellulosic Substrates

Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles

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