Recent Advances in the Chemical Synthesis of β-Nicotinamide Mononucleotide

Abstract

Abstract:: β-Nicotinamide mononucleotide (β-NMN), a key precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+) in mammals, has significant effects in replenishing NAD+ levels in the body, so it has obvious ameliorative effects on metabolic and age-related degenerative diseases. β-NMN is widely used in healthcare products, food, and cosmetics. It has considerable commercial worth and promising medical application prospects. Hence, the development of methods for preparing β-NMN is of great research significance. This review summarized and analyzed recent developments in the chemical synthesis of β-NMN from various starting materials, which could provide helpful references for the investigation of new synthetic techniques for β-NMN and encourage its further development and large-scale application.

Microbial creation of β‐Nicotinamide mononucleotide and its regulation of lipid metabolism in the liver of high‐fat diet mice

“…Chemical synthesis is the principal commercial method for producing NMN, although it raises significant environmental and safety concerns. 18,19 With the rapid development of synthetic biology, the manufacturing of NMN via microbial cell factories can be cost-effective, efficient, and environmentally friendly. The utilization of microbial cell factories to produce NMN is mostly based on the reaction pathway of 5phosphoribosyl 1-pyrophosphate (PRPP) and Nicotinamide (NAM), catalyzed by Nicotinamide phosphoribosyltransferase (NAMPT).…”

“…Currently, NMN synthesis primarily involves chemical and biological pathways. Chemical synthesis is the principal commercial method for producing NMN, although it raises significant environmental and safety concerns 18,19 . With the rapid development of synthetic biology, the manufacturing of NMN via microbial cell factories can be cost‐effective, efficient, and environmentally friendly.…”

Synthesis of NMN by cascade catalysis of intracellular multiple enzymes

“…2,6 Because of its various functions, NMN has broad application prospects in the elds of nutrition, health food and even medicine. 7 In recent years, increasing attention has been paid to the synthesis methods of NMN. At present, the highest yield of NMN is obtained by applying the chemical synthesis method, such as the Ketalization reagent method.…”

“…2,6 Because of its various functions, NMN has broad application prospects in the fields of nutrition, health food and even medicine. 7…”