Recent advances in the chemistry of selenium-containing heterocycles: Six-membered ring systems

Organoselenium Compounds: Chemistry and Applications in Organic Synthesis

“…Most of the mechanisms of action of selenium‐containing molecules involve radical species including the thioredoxin system that catalyzes a number of physiological reactions in living organisms. In fact, selenium‐containing heterocycles are attracting attention due to their fascinating chemistry and potential pharmacological relevance [574–576] . The key role in regulating the redox balance that is associated with cell proliferation, tumor genesis, and angiogenesis, and other ones makes this system a relevant target for potential use in cancer chemotherapy [577] .…”

“…In fact, selenium-containing heterocycles are attracting attention due to their fascinating chemistry and potential pharmacological relevance. [574][575][576] The key role in regulating the redox balance that is associated with cell proliferation, tumor genesis, and angiogenesis, and other ones makes this system a relevant target for potential use in cancer chemotherapy. [577] Initial toxicity associated to oraganoselenium compounds could have limitated their use in medicinal chemistry; however, there are many examples where selenium-containing molecules exhibit vanishing toxicity.…”

Regio- and Stereoselective Synthesis of 3-Selenylazaflavanones and 3-Selenylflavanones via Electrochemically Facilitated Selenylation Cascade

“…Therefore, the prominence of these compounds has led to great interest in their synthesis, and two main known strategies have been developed, including transition-metal catalyzed conjugated 1,4-addition and intramolecular aza-Michael addition of substituted-chalcone analogues . On the other hand, selenium-containing heterocycles have recently attracted increasing attention as the introduction of selenium groups could affect the physicochemical properties of heterocyclic compounds, making them exhibit more interesting biological activities . Moreover, heterocyclic compounds with C–Se bonds can also facilitate further derivatives via radical substitution or oxidative elimination reactions due to the unique reactivity of the C–Se bonds .…”

Natural Compounds and Their Structural Analogs in Regio- and Stereoselective Synthesis of New Families of Water-Soluble 2H,3H-[1,3]thia- and -Selenazolo[3,2-a]pyridin-4-ium Heterocycles by Annulation Reactions

“…Selenium analogs, [1,3]selenazolo [3,2-a]pyridinium derivatives are less studied. Selenium-containing heterocycles [9][10][11][12][13] represent an important family of compounds exhibiting various types of biological activity including anti-inflammatory, antitumor, antifungal, and glutathione peroxidase-like action [12][13][14][15][16][17][18][19][20]. The selenium-containing heterocyclic drug ebselen is [9][10][11][12][13] represent an important family of compounds exhibiting various types of biological activity including anti-inflammatory, antitumor, antifungal, and glutathione peroxidase-like action [12][13][14][15][16][17][18][19][20].…”