Recent advances in the colorimetric and fluorescence analysis of bioactive small-molecule compounds based on the enzyme-like activity of nanomaterials

Colorimetric Sensors: Methods and Applications

“…In addition, many small molecules, including adenine phosphate, vitamin B3, and vitamin B6, were found to possess POD-like activity in our previous studies, which were successfully applied in the colorimetric detection of hydrogen peroxide, ascorbic acid, and glutathione, as well as total antioxidant capacity evaluation, respectively. Therefore, modifications of nanomaterials using these small molecules to increase their enzyme-like activity or endow them with multiple enzyme-like activity have great potential in improving the sensitivity and selectivity of related colorimetric detection methods [ 1 ].…”

“…Colorimetric sensors have attracted considerable attention in many sensing applications because of their specificity, high sensitivity, cost-effectiveness, ease of use, rapid analysis, simplicity of operation, and clear visibility to the naked eye [ 1 ]. A number of colorimetric sensors have been developed for the detection of metal and non-metal ions [ 2 , 3 ], proteins [ 4 ], small molecules [ 5 , 6 ], gases [ 7 ], viruses and bacteria [ 8 , 9 ], DNA/RNA [ 10 , 11 , 12 ], reactive oxygen species and acidity/base [ 13 ], as well as the biomarkers in clinical diagnostics [ 14 , 15 , 16 ].…”