Recent advances in the development and application of peptide self-assemblies in infection control

Ge, Tianhao; Hu, Xuzhi; Liao, Mingrui; Zhou, Feng; Lu, Jian Ren

doi:10.1016/j.cocis.2023.101745

Cited by 12 publications

(3 citation statements)

References 74 publications

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“…40 Peptides by their nature are susceptible to enzymatic degradation and also known to induce an off-target immune response. Self-assembling peptides have the potential to minimize enzymatic degradation, 41 and engineering their surface functionality along with charge characteristics can affect their immunogenicity. 42 ■ SELF-ASSEMBLED HYDROGELS Hydrogels are three-dimensional cross-linked networks that can retain water molecules within their structure.…”

Section: ■ Self-assembled Lipid-based Nanomaterialsmentioning

confidence: 99%

Self-Assembled Nanobiomaterials for Combination Immunotherapy

Paul V,

Sharma,

Shanavas

2023

ACS Appl. Bio Mater.

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Nanotechnological interventions for cancer immunotherapy are a rapidly evolving paradigm with immense potential. Self-assembled nanobiomaterials present safer alternatives to their nondegradable counterparts and pose better functionalities in terms of controlled drug delivery and phototherapy to activate immunogenic cell death. In this Review, we discuss several classes of self-assembled nanobiomaterials based on polymers, lipids, peptides, hydrogel, metal organic frameworks, and covalent−organic frameworks with the ability to activate systemic immune response and convert a "cold" immunosuppressive tumor mass to a "hot" antitumor immune cell rich microenvironment. The unique aspects of these materials are underpinned, and their mechanisms of combinatorial immunotherapeutic action are discussed. Future challenges associated with their clinical translation are also highlighted.

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Section: ■ Self-assembled Lipid-based Nanomaterialsmentioning

confidence: 99%

Self-Assembled Nanobiomaterials for Combination Immunotherapy

Paul V,

Sharma,

Shanavas

2023

ACS Appl. Bio Mater.

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“…7,8 In the past, research on the individual protection in outdoor spaces has attracted much attention, such as the design of face mask. 9 However, more studies must also be undertaken to understand how to protect us in enclosed small spaces, such as research laboratories and hospitals. 10,11 These areas require highly efficient filtration tools to keep air clean during the circulation process.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, air pollution caused by fine particulate matter has become one of the most serious environmental concerns in the world. − The fine particle pollutants in the air, especially particles with an aerodynamic diameter smaller than 2.5 μm (PM2.5), have been shown to be the main causes of cancer, fibrosis, and chronic lung disease . In addition, fine particulate pollutants in the atmosphere also contain various microorganisms, such as Streptococcus pyogenes, Mycobacterium tuberculosis, and Bordetella pertussis, increasing the risk level of air-borne infections. , In the past, research on the individual protection in outdoor spaces has attracted much attention, such as the design of face mask . However, more studies must also be undertaken to understand how to protect us in enclosed small spaces, such as research laboratories and hospitals. , These areas require highly efficient filtration tools to keep air clean during the circulation process.…”

Section: Introductionmentioning

confidence: 99%

Hierarchically Porous, Superhydrophobic PLLA/Copper Composite Fibrous Membranes for Air Filtration

Huang,

Meng,

Liao

et al. 2024

ACS Appl. Polym. Mater.

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Epidemics such as pulmonary tuberculosis and pertussis can spread quickly through the air in enclosed or small spaces. Most of these diseases are caused by various bacteria. In hospitals, nursing homes, and biology laboratories, the requirement for air quality is often high. Particulate air filters can remove infectious bacteria from the air, making them a good choice for local ventilation systems to capture and remove bacteria or other pathogenic microbes. With high surface area, electrospun poly(l-lactic acid) (PLLA) fibrous membranes have the ability to capture small particles like bacteria. Moreover, copper has significant antimicrobial properties. In this Letter, we present a hierarchically porous PLLA membrane created through electrospinning and acetone treatment. Additionally, we describe two methods for loading copper particles onto the hierarchically porous PLLA membrane, thereby providing capabilities for capturing and killing bacteria. The experiments demonstrated that the final PLLA/Cu composite fibrous membranes exhibit not only excellent air permeability but also remarkable antimicrobial performance while maintaining bendability and superhydrophobic ability. This study provides a simple process, low energy cost, and environmentally friendly method to produce the copper-coated PLLA membrane, which is especially suitable for potential applications in high-flux filtration equipment in hospitals, nursing homes, and biology laboratories.

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