Recent advances in the development and application of nanoelectrodes

Fan, Yunshan; Han, Choong‐Hee; Zhang, Bo

doi:10.1039/c6an01285j

Cited by 49 publications

(30 citation statements)

References 126 publications

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“…[68] This effect can be attributed to a decrease in the interfacial capacitance, which in turn directly correlates with the area of the electrode. [69] For this reason, meso-and nanoporous electrodes with the high surface area have been the subject of intense research in the last years. [70,71] Miniaturizing the electrodes surface area is essential to match the infectious dose of bacteria, which for many human pathogens is as low as 1-10 colonyforming unit per milliliters (CFU mL -1 ).…”

Section: Miniaturizationmentioning

confidence: 99%

Bacterial Sensing and Biofilm Monitoring for Infection Diagnostics

Parlak

Richter‐Dahlfors

2020

Macromolecular Bioscience

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Recent insights into the rapidly emerging field of bacterial sensing and biofilm monitoring for infection diagnostics are discussed as well as recent key developments and emerging technologies in the field. Electrochemical sensing of bacteria and bacterial biofilm via synthetic, natural, and engineered recognition, as well as direct redox-sensing approaches via algorithmbased optical sensing, and tailor-made optotracing technology are discussed. These technologies are highlighted to answer the very critical question: "how can fast and accurate bacterial sensing and biofilm monitoring be achieved? Following on from that: "how can these different sensing concepts be translated for use in infection diagnostics? A central obstacle to this transformation is the absence of direct and fast analysis methods that provide high-throughput results and bio-interfaces that can control and regulate the means of communication between biological and electronic systems. Here, the overall progress made to date in building such translational efforts at the level of an individual bacterial cell to a bacterial community is discussed.

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Section: Miniaturizationmentioning

confidence: 99%

Bacterial Sensing and Biofilm Monitoring for Infection Diagnostics

Parlak

Richter‐Dahlfors

2020

Macromolecular Bioscience

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“…Suitable nanodisc electrodes are obviously more difficult to fabricate and handle. A collection of recent comprehensive reviews as the source of details on nanoelectrode fabrication, their electrochemical behaviour and potential applications can be found in [33][34][35][36][37]. The operation of nanodisc electrodes on single cells requires the preservation of a nanometre tip-to-sample working distance for the entire duration of lateral tip displacement relative to the fixed biological sample.…”

Section: (A) Constant-height Mode Cellular Scanning Electrochemical Mmentioning

confidence: 99%

Biological imaging with scanning electrochemical microscopy

2018

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Scanning electrochemical microscopy (SECM) is a powerful and versatile technique for visualizing the local electrochemical activity of a surface as an ultramicroelectrode tip is moved towards or over a sample of interest using precise positioning systems. In comparison with other scanning probe techniques, SECM not only enables topographical surface mapping but also gathers chemical information with high spatial resolution. Considerable progress has been made in the analysis of biological samples, including living cells and immobilized biomacromolecules such as enzymes, antibodies and DNA fragments. Moreover, combinations of SECM with complementary analytical tools broadened its applicability and facilitated multi-functional analysis with extended life science capabilities. The aim of this review is to present a brief topical overview on recent applications of biological SECM, with particular emphasis on important technical improvements of this surface imaging technique, recommended applications and future trends.

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“…Electrochemistry with nanoelectrode has attracted signicantly increasing attention for its unique advantages (e.g. high spatiotemporal resolution, high sensitivity, minimum damage to cells) [31][32][33][34][35][36] in real time monitoring of molecular events at multiple-scale (cell populations, single cell and subcellular) levels. [37][38][39][40][41][42][43][44][45][46][47][48] Further combining with scanning electrochemical microscopy (SECM) or scanning ion conductance microscopy (SICM) allows electrochemical and topographical imaging of neurons and detection of neurotransmitter release with super resolution.…”

Section: Introductionmentioning

confidence: 99%