Recent Advances In the development of enzymatic paper-based microfluidic biosensors

Aghababaie, Marzieh; Foroushani, Elnaz Sarrami; Changani, Zinat; Gunani, Zahra; Mobarakeh, Mahsa Salehi; Hadady, Hanieh; Khedri, Mohammad; Maleki, Reza; Asadnia, Mohsen; Razmjou, Amir

doi:10.1016/j.bios.2023.115131

Cited by 14 publications

(2 citation statements)

References 149 publications

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“…Apart from the barrier creation, the inkjet method can be used to simultaneously print biomolecules, biomarkers, and immunoassay reagents on the paper microzones, thereby creating complete biosensing platforms. 122 Hossain et al first demonstrated the development of bioinks and bioactive papers for rapid detection of neurotoxins and pesticides in food. 123,124 Later, omniphobic flouroalkylated (R F ) papers printed with high resolution conductive patterns were developed by Lessing et al 125 Inkjet printing has become a powerful technique for defining immuno-chemical and conductive circuits directly on paper.…”

Section: Inkjet Printingmentioning

confidence: 99%

Microfluidic paper analytic device (μPAD) technology for food safety applications

Soman,

Samad,

Venugopalan

et al. 2024

Biomicrofluidics

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Foodborne pathogens, food adulterants, allergens, and toxic chemicals in food can cause major health hazards to humans and animals. Stringent quality control measures at all stages of food processing are required to ensure food safety. There is, therefore, a global need for affordable, reliable, and rapid tests that can be conducted at different process steps and processing sites, spanning the range from the sourcing of food to the end-product acquired by the consumer. Current laboratory-based food quality control tests are well established, but many are not suitable for rapid on-site investigations and are costly. Microfluidic paper analytical devices (μPADs) are a fast-growing field in medical diagnostics that can fill these gaps. In this review, we describe the latest developments in the applications of microfluidic paper analytic device (μPAD) technology in the food safety sector. State-of-the-art μPAD designs and fabrication methods, microfluidic assay principles, and various types of μPAD devices with food-specific applications are discussed. We have identified the prominent research and development trends and future directions for maximizing the value of microfluidic technology in the food sector and have highlighted key areas for improvement. We conclude that the μPAD technology is promising in food safety applications by using novel materials and improved methods to enhance the sensitivity and specificity of the assays, with low cost.

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Section: Inkjet Printingmentioning

confidence: 99%

Microfluidic paper analytic device (μPAD) technology for food safety applications

Soman,

Samad,

Venugopalan

et al. 2024

Biomicrofluidics

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“…This strategy eliminates the need for additional reagents during the sensing process [17,18], offering flexible fabrication methods for biosensors by precisely positioning a small amount of materials, and takes advantage of controlling the unnecessary wastage of enzymes and potential contamination [19]. In recent years, a number of enzyme-based glucose sensors have been developed for diabetes diagnosis [11,20]. Bihar E, et al [21] used inkjet-printing technology for the rapid and low-cost deposition of all the components of this glucose sensor, from the electronics to the biorecognition elements, on commercially available paper substrates.…”

Section: Introductionmentioning

confidence: 99%

Enzyme Immobilization by Inkjet Printing on Reagentless Biosensors for Electrochemical Phosphate Detection

Zhang,

Bai,

Niu

et al. 2024

Biosensors

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Enzyme-based biosensors commonly utilize the drop-casting method for their surface modification. However, the drawbacks of this technique, such as low reproducibility, coffee ring effects, and challenges in mass production, hinder its application. To overcome these limitations, we propose a novel surface functionalization strategy of enzyme crosslinking via inkjet printing for reagentless enzyme-based biosensors. This method includes printing three functional layers onto a screen-printed electrode: the enzyme layer, crosslinking layer, and protective layer. Nanomaterials and substrates are preloaded together during our inkjet printing. Inkjet-printed electrodes feature a uniform enzyme deposition, ensuring high reproducibility and superior electrochemical performance compared to traditional drop-casted ones. The resultant biosensors display high sensitivity, as well as a broad linear response in the physiological range of the serum phosphate. This enzyme crosslinking method has the potential to extend into various enzyme-based biosensors through altering functional layer components.

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Fe/Pt-doped carbon nanoparticles with peroxidase-like activity for point-of-care determination of uric acid

Tong,

Li,

Guo

et al. 2024

Microchim Acta

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Recent Advances In the development of enzymatic paper-based microfluidic biosensors

Cited by 14 publications

References 149 publications

Microfluidic paper analytic device (μPAD) technology for food safety applications

Microfluidic paper analytic device (μPAD) technology for food safety applications

Enzyme Immobilization by Inkjet Printing on Reagentless Biosensors for Electrochemical Phosphate Detection

Fe/Pt-doped carbon nanoparticles with peroxidase-like activity for point-of-care determination of uric acid

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