Recent advances in the diagnosis and management of pre-eclampsia

Hurrell, Alice; Duhig, Kate; Vandermolen, Brooke; Shennan, Andrew

doi:10.12703/b/9-10

Cited by 14 publications

(12 citation statements)

References 23 publications

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“…There is fetal growth restriction been noticed in the cases. The proteinuria formation is not a mandatory part of the recently revised definition of preeclampsia 11,13 .…”

Section: Discussionmentioning

confidence: 99%

Fetal Outcome in Patients with Pre-Eclampsia at Ayub Teaching Hospital Abbottabad

Rafiq¹,

Khan²,

Bibi³

et al. 2022

PJMHS

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Aim: To determine the frequency of fetal outcome in patients presented with pre-eclampsia. Study design: Descriptive cross-sectional study Place and duration of study: Department of Obstetrics & Gynecology, Ayub Teaching Hospital Abbottabad from 4th May 2020 to 4th November 2020. Methodology: One hundred and twenty six pre-eclamptic patients aged 18-45 years having gestational age more than 20 weeks were enrolled. Detailed demographics were recorded after taking informed written consent. Fetal outcomes were examined. Data was analysed by SPSS 22.0. Results: Mean age of patients was 27.48±5.618 years with mean gestational age of 35.056±2.9554 ranging from 31.2 to 41.1 weeks. Mean systolic blood pressure was 151.98±8.85 and mean diastolic blood pressure was 96.90±4.64. Mean proteinuria was 170.56±105.92. The frequency of preterm birth was 26 (20.6%), LBW was found in 52.4% patients, IUGR was found in 25.4%, birth asphyxia was found in 19% patients and still birth was found in 16.7%. Conclusion: Pre-eclampsia can lead to major fetal and maternal complications. We found in our study that low birth weight, preterm birth and IUGR were the most common adverse fetal outcomes. Keywords: Fetal outcome, Birth asphyxia, Stillbirth, Preterm birth, Low birth weight, Pre-eclampsia

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“…There is fetal growth restriction been noticed in the cases. The proteinuria formation is not a mandatory part of the recently revised definition of preeclampsia 11,13 .…”

Section: Discussionmentioning

confidence: 99%

Fetal Outcome in Patients with Pre-Eclampsia at Ayub Teaching Hospital Abbottabad

Rafiq¹,

Khan²,

Bibi³

et al. 2022

PJMHS

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“…But from progressive ongoing research, we understand that the development of early-onset and late-onset preeclampsia along with IUGR does not compulsorily indicate a common origin of etiology [ 35 ]. In spite of many ongoing kinds of research, the pathogenesis, diagnosis, and prevention of preeclampsia remain puzzling [ 36 ]. But much current evidence indicates that there can be many underlying etiologies or predisposing factors that can lead to endothelial malfunctioning and give rise to a group of symptoms such as high blood pressure, protein in urine, and edema.…”

Section: Reviewmentioning

confidence: 99%

Study of Histopathological Changes in the Placenta in Preeclampsia

Bhojwani¹,

Agrawal²

2022

Cureus

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Pregnancy disorders include, most commonly, hypertensive disorders, which include gestational hypertension, preeclampsia, and chronic hypertension with superimposed preeclampsia. Various etiological factors prove to be both risks as well as protective factors, which include genetic factors, maternal smoking (it is inversely related to preeclampsia; that is, smoking decreases the incidence of preeclampsia), and other medical comorbidities such as hypertension, diabetes, asthma, and others, including older maternal age and high body mass index. Usually, high maternal and fetal mortality rates are seen with the diagnosis of hypertensive disorders in pregnancy, and severe morbidity is seen in cases of preeclampsia, eclampsia, and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count), along with raised levels of liver enzymes and blood disorders such as low platelet counts. Preeclampsia is considered one of the most serious consequences of pregnancy. These disorders are often presented as newly diagnosed high blood pressure and proteinuria during the last trimester. But it can prove to be fatal for both the mother and the fetus. Though the causative factors of preeclampsia are still unknown, specific clinical and histopathological researchers propose that preeclampsia can be due to pathological changes in the placenta. The basic aim of this article is to discuss various histopathological changes in the placenta due to preeclampsia, but minor topics that affect the pathophysiology of the placenta due to preeclampsia are also mentioned. Furthermore, the effective management of maternal syndrome complications in pregnancy has also been discussed.

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“…In preeclampsia, circulating levels of sFlt1 tend to be increased while circulating PIGF levels are reduced [8,9]. The measurement of PIGF can be used for risk stratification and substantially reduces the time to diagnosis of preeclampsia [46][47][48][49]. In some countries, the ratio of sFlt1/PIGF is recommended as diagnostic criterion to differentiate preeclampsia cases from non-preeclamptic pregnancies [50].…”

Section: Diagnosis Of Preeclampsiamentioning

confidence: 99%

“…Likewise, low PIGF should not be considered as a sufficient criterion to perform immediate delivery [52]. Taken together, angiogenic biomarker testing combined with risk stratification substantially reduces the time to diagnosis so that suspected preeclampsia can be considered much earlier and even before proteinuria develops [49].…”

Section: Diagnosis Of Preeclampsiamentioning

confidence: 99%

Pathological AT1R-B2R Protein Aggregation and Preeclampsia

Quitterer

AbdAlla

2021

Cells

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Preeclampsia is one of the most frequent and severe complications of pregnancy. Symptoms of preeclampsia usually occur after 20 weeks of pregnancy and include hypertension and kidney dysfunction with proteinuria. Up to now, delivery of the infant has been the most effective and life-saving treatment to alleviate symptoms of preeclampsia because a causative treatment does not exist, which could prolong a pregnancy complicated with preeclampsia. Preeclampsia is a complex medical condition, which is attributed to a variety of different risk factors and causes. Risk factors account for insufficient placentation and impaired vasculogenesis and finally culminate in this life-threatening condition of pregnancy. Despite progress, many pathomechanisms and causes of preeclampsia are still incompletely understood. In recent years, it was found that excessive protein complex formation between G-protein-coupled receptors is a common sign of preeclampsia. Specifically, the aberrant heteromerization of two vasoactive G-protein-coupled receptors (GPCRs), the angiotensin II AT1 receptor and the bradykinin B2 receptor, is a causative factor of preeclampsia symptoms. Based on this knowledge, inhibition of abnormal GPCR protein complex formation is an experimental treatment approach of preeclampsia. This review summarizes the impact of pathological GPCR protein aggregation on symptoms of preeclampsia and delineates potential new therapeutic targets.

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Recent advances in the diagnosis and management of pre-eclampsia

Cited by 14 publications

References 23 publications

Fetal Outcome in Patients with Pre-Eclampsia at Ayub Teaching Hospital Abbottabad

Fetal Outcome in Patients with Pre-Eclampsia at Ayub Teaching Hospital Abbottabad

Study of Histopathological Changes in the Placenta in Preeclampsia

Pathological AT1R-B2R Protein Aggregation and Preeclampsia

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