Recent advances in the endocrinology of the sebaceous gland

Szöllősi, Attila Gábor; Oláh, Attila; Bı́ró, Tamás; Tóth, Balázs István

doi:10.1080/19381980.2017.1361576

Cited by 34 publications

(41 citation statements)

References 96 publications

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“…The insulin/IGF‐1 interaction with the respective receptors, the insulin (IR) and the IGF1 receptor (IGF‐1R) activates the phosphatidylinositide 3‐kinase‐Akt (PI3K/Akt) pathway, the mammalian target of rapamycin (mTOR) and, subsequently, the transcription factor sterol response element‐binding protein 1 (SREBP1) . In vitro , insulin induces sebogenesis and inflammation in the human immortalized sebocyte cell line SZ95 . In vivo , mTOR signalling is up‐modulated in affected and non‐affected skin of acne patients correlated with an increased value of mean homoeostatic model assessment of insulin resistance, indicating the hyper‐activation of the pathway.…”

Section: Introductionmentioning

confidence: 99%

“…9 In vitro, insulin induces sebogenesis and inflammation in the human immortalized sebocyte cell line SZ95. 14,[19][20][21][22] In vivo, mTOR signalling is up-modulated in affected and nonaffected skin of acne patients correlated with an increased value of mean homoeostatic model assessment of insulin resistance, 3,16,[23][24][25][26] indicating the hyper-activation of the pathway.…”

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confidence: 99%

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Sebocyte differentiation as a new target for acne therapy: an in vivo experience

Ottaviani

Flori

Mastrofrancesco

et al. 2020

Acad Dermatol Venereol

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Background Acne, a disease of the sebaceous gland with multifactorial pathogenesis, affects more than 85% of adolescents. A better deepening of the mechanisms underlying the disease is needed to define effective and mechanismtargeted treatments. Objective To understand whether the sebocyte differentiation process could be involved in the pathogenesis of the disease. Methods Protein expressions were evaluated by Western blot analysis and ELISA; mRNA levels by real-time RT-PCR, lipid analysis and lipid peroxidation were performed by gas chromatography, mass spectrometry and spectrophotometric assay. Results In vitro, low differentiated SZ95 sebocyte expressed an up-modulation of genes involved in sebogenesis and a higher level of insulin receptor respect to differentiated cells, resulting in an increased response to insulin and in the production of acne-like sebum. The induction of SZ95 sebocyte differentiation by the peroxisome proliferator-activated receptor c (PPARc) modulator NAC-GED0507 reduced the response to insulin normalizing the sebum production and decreasing the release of proinflammatory mediators. In vivo treatment of acne patients with NAC-GED0507 1% gel ameliorated clinical manifestations and induced in sebum the expression of PPARc, associated with the decrease in mammalian target of rapamycin activation and levels of inflammatory molecules, confirming the results obtained in vitro. Conclusions The study provides relevant insight into acne pathogenesis, identifying an alteration of sebocyte differentiation as pathogenetic basis of the disease and the induction of the differentiation process as a therapeutic target in acne therapy interfering with all pathogenic mechanisms.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Sebocyte differentiation as a new target for acne therapy: an in vivo experience

Ottaviani

Flori

Mastrofrancesco

et al. 2020

Acad Dermatol Venereol

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“…There were also only 5/39 dogs under 12 months of age, and the groups were not age or gender matched. It is not known how these variables may have impacted the lipid pro les obtained but it is known from human studies that skin lipids vary with age and gender [26,27,28]. Lipid pro les also vary between body sites [13] and, in an untargeted human study, lipids varied depending on sebaceous gland density [29].…”

Section: Discussionmentioning

confidence: 99%

An untargeted investigation into the skin surface lipidome in the West Highland white terrier dog, with and without atopic dermatitis

Orbell

Cave

Parry

et al. 2020

Preprint

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Background – The skin barrier is important in the pathogenesis of atopic dermatitis and stratum corneum lipids have a critical role. Skin surface lipids have been largely overlooked but also contribute to barrier function. An untargeted approach was used to compare the skin surface lipids from atopic and non-atopic West Highland White terrier dogs. The primary hypothesis was that a difference in the lipidome of atopic and non-atopic dogs would be found and the secondary hypothesis was that affected and unaffected skin would differ in lipid profile.Results – Thirty-nine dogs were classified into one of four disease status groups based on strict criteria. Samples for lipid analysis were collected from affected and unaffected skin, and liquid chromatography/mass spectrometry found 421 lipid soluble features. Ten lipids were positively identified. Statistical analysis could not distinguish between non-atopic and atopic dogs. Partial least squares-discriminant analysis revealed a difference in the lipid profiles from affected and non-affected skin irrespective of disease status. Conclusions – An untargeted approach found a large array of unidentified lipids from the skin surface. There was a difference in the lipidome between affected and unaffected skin that was not related to disease status. Investigation into the lipidome of the skin surface in health and disease is an emerging area of research which could have clinical and therapeutic applications.

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“…In this case, a lower level of serum testosterone reduces sebum production in sebaceous glands [134]. The second mechanism explains that chromium as an anti-depressant [135][136][137] may reduce sebum production [138] and affect C. acnes growth in sebaceous glands [122][123][124]. It is clearly showed that these two mechanisms may have direct or indirect synergistic effects [139] in ameliorating skin condition with acne vulgaris.…”

Section: Biological Activities Of Chromium 41 Acne Vulgaris (Antiacne)mentioning

confidence: 97%

Dermatologic Toxicities and Biological Activities of Chromium

Jumina¹,

Harizal²

2021

Trace Metals in the Environment - New Approaches and Recent Advances

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Chromium is a versatile metal with various industrial applications and biological activities. However, as a transition metal, this element forms several species, i.e. oxidation states of −4 to +6, with different degrees of toxicities that affect ecosystems and organisms including human beings. The skin is the outermost organ that usually interacts directly with chromium species in nature. These contact and interaction induce the formation of several acute and chronic negative effects including contact dermatitis, skin cancer, allergy, etc. In this chapter, toxicity and biological activity of several chromium species, such as chromium zero-valent, trivalent, hexavalent, will be reviewed to obtain better comprehension in chromium toxicity. Sources and routes of exposure, toxicity and possible treatment, and biological activity on the skin are arranged and explained systematically.

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Recent advances in the endocrinology of the sebaceous gland

Cited by 34 publications

References 96 publications

Sebocyte differentiation as a new target for acne therapy: an in vivo experience

Sebocyte differentiation as a new target for acne therapy: an in vivo experience

An untargeted investigation into the skin surface lipidome in the West Highland white terrier dog, with and without atopic dermatitis

Dermatologic Toxicities and Biological Activities of Chromium

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