Recent Advances in the Extraction of Pittosporum angustifolium Lodd. Used in Traditional Aboriginal Medicine: A Mini Review

Abstract

Numerous native Australian plants are widely used as traditional medicines by the Australian Aboriginal and Torres Strait Islander peoples. Among the native plants, Pittosporum angustifolium Lodd. (Gumby Gumby) is claimed to be a promising medicinal plant in the treatment of a wide range of diseases that includes viral symptoms (colds and coughs), eczema, cancer, muscle aches, varicose veins, and many more. Various extraction techniques are used to extract the bioactive compounds of P. angustifolium, which are formulated into nutraceuticals. The present paper will provide an overview of the recent development in the extraction of bioactive ingredients from P. angustifolium, as well as the findings on the phytochemicals and antimicrobial activity of P. angustifolium extracts.

Bioassay-Guided Fractionation of Pittosporum angustifolium and Terminalia ferdinandiana with Liquid Chromatography Mass Spectroscopy and Gas Chromatography Mass Spectroscopy Exploratory Study

“…These compounds are known for their strong antioxidant, anticancer, anti-inflammatory, and antifungal properties [ 16 ]. Previous studies have also identified chlorogenic acid in P. angustifolium leaves [ 17 , 18 , 19 ]. Additionally, our previous work has suggested the presence of chlorogenic acid in crude MeOH extracts of P. angustifolium leaves [ 14 , 20 ].…”

“…On the other hand, the subfractions could contain fewer isolated compounds, which may explain the low or no cytotoxicity observed. Although numerous studies have identified triterpenoid saponins, terpenoids, phenols, and coumarin compounds isolated from P. angustifolium as having potential anticancer properties [10,17,18,35,36], only a few have been shown to be effective in vitro. Backer et al (2016) screened ten acylated saponins for their ability to inhibit human DNAtopoisomerase I, an enzyme responsible for resolving torsional stress associated with DNA replication, transcription, and chromatin condensation [37].…”

“…In addition, authentic standards of selected polyphenols (4-hydroxybenzoic acid, caffeic acid, catechin, catechol, chlorogenic acid, gallic acid, isovanillic acid, neochlorogenic acid, protocatechuic acid, syringic acid, tyrosol and vanillic acid) were subjected to the same HPLC gradient elution as the subfractions, and the combined chromatograms with retention times are shown in Figure 7. When compared to the retention times of the predominant peaks in the chromatograms of the subfractions (Figure 6), only one peak at a Although numerous studies have identified triterpenoid saponins, terpenoids, phenols, and coumarin compounds isolated from P. angustifolium as having potential anticancer properties [10,17,18,35,36], only a few have been shown to be effective in vitro. Backer et al (2016) screened ten acylated saponins for their ability to inhibit human DNA-topoisomerase I, an enzyme responsible for resolving torsional stress associated with DNA replication, transcription, and chromatin condensation [37].…”