The study aims to explore the application effect of nursing model based on Rockall scoring system in the emergency endoscopic treatment for patients with gastrointestinal bleeding. 128 patients with gastrointestinal bleeding in the emergency department of our hospital were selected as the study subjects. The patients were divided into the control group (64 cases) treated with routine bleeding management and the observation group (64 cases) treated with the nursing model based on Rockall scoring system by utilizing random number table. The hemostatic time, hospital stay, hemostasis, blood transfusion rate, rebleeding rate, mortality rate and Rockall score, Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS) score and nursing satisfaction were compared between the observation and control groups. The results turn out that the hemostatic time, hospital stay, hemostasis, blood transfusion rate, rebleeding rate, mortality rate and Rockall score were notably better than those in the control group. SDS and SAS scores in the observation group were prominently higher than that of the control group, and the satisfaction rate of nursing services of the observation group was higher than that of the control group. The nursing model based on Rockall scoring system could shorten the emergent hemostasis time and hospital stay, elevate recovery effect, and reduce the times of blood transfusion, the rebleeding rate and mortality of patients. Besides, it could lower the risk level of bleeding, improve the mental health status and satisfaction of patients with a great clinical practical value, which is worthy of clinical application.