Recent Advances in the Neurobiology of Altered Motivation Following Bariatric Surgery

Brutman, Julianna N.; Sirohi, Smita; Davis, Jon F.

doi:10.1007/s11920-019-1084-2

Cited by 16 publications

(11 citation statements)

References 126 publications

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“…[5][6][7][8][9][10][11][12]. However, our understanding of the impact of bariatric surgery on the central nervous system, more specifically on brain reward pathways, is limited (13).…”

Section: Introductionmentioning

confidence: 99%

Taste-related reward is associated with weight loss following bariatric surgery

Smith

Papantoni

Veldhuizen

et al. 2020

Journal of Clinical Investigation

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BACKGROUND. Bariatric surgeries are the most effective treatments for successful and sustained weight loss, but individuals vary in treatment response. Understanding the neurobiological and behavioral mechanisms accounting for this variation could lead to the development of personalized therapeutic approaches and improve treatment outcomes. The primary objectives of this study were to investigate changes in taste preferences and taste-induced brain responses after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) and to identify potential taste-related predictors of weight loss. METHODS.Females, ages 18 to 55, with a body mass index greater than or equal to 35 kg/m 2 , and approved for bariatric surgery at the Johns Hopkins Center for Bariatric Surgery were recruited for participation. Demographics, anthropometrics, liking ratings, and neural responses to varying concentrations of sucrose plus fat mixtures were assessed before and after surgery via visual analog scales and functional MRI. RESULTS.Bariatric surgery produced decreases in liking for sucrose-sweetened mixtures. Greater preference for sucrosesweetened mixtures before surgery was associated with greater weight loss in RYGB, but not VSG. In the RYGB group only, individuals who showed lower taste-induced activation in the ventral tegmental area (VTA) before surgery and greater changes in taste-induced VTA activation 2 weeks following surgery experienced increased weight loss. CONCLUSION.The anatomical and/or metabolic changes associated with RYGB may more effectively "reset" the neural processing of reward stimuli, thereby rescuing the blunted activation in the mesolimbic pathway found in patients with obesity. Further, these findings suggest that RYGB may be particularly effective in patients with a preference for sweet foods.

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“…[5][6][7][8][9][10][11][12]. However, our understanding of the impact of bariatric surgery on the central nervous system, more specifically on brain reward pathways, is limited (13).…”

Section: Introductionmentioning

confidence: 99%

Taste-related reward is associated with weight loss following bariatric surgery

Smith

Papantoni

Veldhuizen

et al. 2020

Journal of Clinical Investigation

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“…8% dos mesmos ficaram mais expostos e se encaminharam a desenvolver o uso crônico por opióides, pontuação está mais elevada que população geral de 3% da amostragem. Os dados sugerem que os procedimentos bariátricos possuem a capacidade de modular diferentemente a forma gástrica e intestinal no consumo de álcool e medicamentos (BRUTMAN JN, et al, 2019).…”

Section: Discussionunclassified

Cirurgia Bariátrica e sua correlação com o abuso de substâncias

Araujo¹,

Morais²,

Sousa³

2022

Acervo Saúde

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Objetivo: Avaliar e abordar os eventos moduladores da cirurgia bariátrica e sua correlação com o desenvolvimento desses abusos. Métodos: O estudo em questão trata-se de uma revisão integrativa da literatura que ergueu seu pressuposto de pesquisa a partir da pergunta norteadora “A realização da cirurgia bariátrica pode representar um gatilho tornando-se fator de risco para desencadear o vício em substâncias?”, foram encontrados com os Descritores em Ciências da Saúde (DeCS): Bariatric Surgery” e “Substance Abuse” com o operador booleano “AND” nas bases de dados Biblioteca Virtual em Saúde (BVS), Publisher Medline (PUBMED) e EBSCOhost 296 artigos, restando 17 após passagem pelos critérios de inclusão e exclusão. Resultados: No espectro da amostra a cirurgia bariátrica apresentou-se como uma forte influência no desenvolvimento de abuso de substâncias. Apesar de consistentes limitações, foi observado que o Bypass Gástrico em Y de Roux (BGYR) com unanimidade foi o procedimento de maior interferência na modulação desses eventos, além do abuso do álcool como a via mais expressiva. Considerações finais: A influência da bariátrica em conjunto com a narrativa de vida do paciente pré e pós cirurgia, mostrou-se como um viés crucial para o abuso de álcool como de outras substâncias diversas.

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“…Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are the two most frequently performed procedures. Both lead to anatomic modifications of the stomach and the small bowel [ 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Involvement of Helicobacter pylori in Preoperative Gastric Findings on a Bariatric Population

Gómez-Heras

Fernández-Aceñero

González³

et al. 2022

IJERPH

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The prevalence of Helicobacter pylori (Hp) in bariatric patients is common and related to gastric pathology. With preoperative upper gastrointestinal endoscopy (UGE), these pathologies and the presence of Hp are diagnosed. The histopathological study of the UGE biopsies is classified based on the Sydney System, a scoring system that stages chronic gastritis (CG) and precancerous gastric lesions. The objective is to assess the histological findings of gastric biopsies during routine UGE and to determine the involvement of Hp in gastric disorders in patients undergoing bariatric surgery. A multicenter retrospective review of prospectively collected databases was performed. The presence of CG, gastric atrophy (GA), and gastric intestinal metaplasia (GIM) in the study of the biopsies was assessed and correlated with Hp infection. The incidence of Hp among our bariatric population was 36.1%, and it increases with age. The percentage of patients with severe Hp infection is higher in patients with GA or GIM. The Hp eradication rate is also reduced when GA and GIM are present. A histological examination of all the biopsies did not show features of malignancy in any of the cases. Hp is not the only factor involved in the development of gastric pathology in bariatric patients.

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Recent Advances in the Neurobiology of Altered Motivation Following Bariatric Surgery

Cited by 16 publications

References 126 publications

Taste-related reward is associated with weight loss following bariatric surgery

Taste-related reward is associated with weight loss following bariatric surgery

Cirurgia Bariátrica e sua correlação com o abuso de substâncias

Involvement of Helicobacter pylori in Preoperative Gastric Findings on a Bariatric Population

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