Recent advances in the separation and purification of lactic acid from fermentation broth

A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids

“…The reason for the enhanced optical purity of L-lactic acid is perhaps that the activity of D-lactic acid producing enzymes are sensitive to high concentration of salt. Furthermore, high salt concentration resulted in the changes of microbial community and decreased diversity of indigenous microbiota [34,51].…”

Valorization of municipal organic waste into purified lactic acid

“…Separation technologies for purification such as reactive distillation and molecular distillation have been implemented using emulsion liquid membranes (ELM), liquid membranes in Taylor flow and green ionic liquid ELM (Garcia-Aguirre et al, 2020;Komesu et al, 2017c;Li et al, 2021a;Mai et al, 2018;Murali et al, 2017). The combination of these with well-established separation techniques have opened a new window for design and synthesis of more sustainable and energetically efficient downstream separation processes for LA recovery.…”

“…During the ELM based separation processes, ELM is first obtained upon emulsification of two immiscible phases (organic phase and internal phase) and then dispersing ELM into a third phase i.e. continuous feed phase by stirring for the extraction of low concentrated solute molecules (Li et al, 2021a).…”

“…Lactic acid production has been covered using catalysts (Razali and Abdullah, 2017) and fermentation with LAB (Martinez et al, 2013;Peng et al, 2020;Rawoof et al, 2021). Lactic acid purification by downstream processing have been studied (Ghaffar et al, 2014;Jantasee et al, 2017;Komesu et al, 2017a;Kumar et al, 2019;Li et al, 2021a) including prospects for polymer production (Hamad et al, 2018;Kowalewska and Nowacka, 2020;Michalski et al, 2019;Riaz et al, 2018;Yildirim et al, 2018). These reviews concentrate mainly on few steps in the value chain creating a need for a holistic review of these steps from carbon source until downstream processing.…”

Lactic acid production by Carnobacterium sp. isolated from a maritime Antarctic lake using eucalyptus enzymatic hydrolysate

“…pH is one of the main factors affecting lactic acid fermentation considering that the enzyme catalytic activity and metabolic activity of the microorganisms greatly depend on the extracellular pH [ 17 ]. pH control of the fermentation broth during the fermentation process through base titration or lactic acid removal (e.g., extraction, adsorption or electrodialysis) results in higher lactic acid production, yield and productivity [ 11 , 25 ]. Regarding the fermentation operational mode, although batch fermentations have been widely used due to higher production of lactic acid, it has been reported that continuous and fed-batch mode could achieve better production yields compared to batch mode [ 26 ].…”