Recent advances in the superovulation in cattle

Mapletoft, R.J.; Steward, Kristina Bennett; Adams, Gregg P.

doi:10.1051/rnd:2002046

Cited by 202 publications

(164 citation statements)

References 40 publications

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“…The failure of the lamb ovarian response to treatment was found using a 'safe dose' of BPA and a 100-fold lower dose at early postnatal exposure. Several factors, such as healthy, nutritional, and reproductive status, genetic factor, age, stress, hormone used, and dose, may affect the success of superovulatory treatment in females (Mapletoft et al 2002). According to the present results, an additional factor such as the xenoestrogen exposure during a critical developmental period may affect the ovarian response to exogenous hormonal treatment.…”

Section: Discussionmentioning

confidence: 53%

Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs

Rivera¹,

Varayoud²,

Rodríguez³

et al. 2015

Reproduction

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Bisphenol A (BPA) and diethylstilbestrol (DES) are xenoestrogens, which have been associated with altered effects on reproduction. We hypothesized that neonatal xenoestrogen exposure affects the ovarian functionality in lambs. Thus, we evaluated the ovarian response to exogenous ovine FSH (oFSH) administered from postnatal day 30 (PND30) to PND32 in female lambs previously exposed to low doses of DES or BPA (BPA50: 50 mg/kg per day, BPA0.5: 0.5 mg/kg per day) from PND1 to PND14. We determined: i) follicular growth, ii) circulating levels of 17b-estradiol (E 2 ), iii) steroid receptors (estrogen receptor alpha, estrogen receptor beta, and androgen receptor (AR)) and atresia, and iv) mRNA expression levels of the ovarian bone morphogenetic protein (BMPs) system (BMP6, BMP15, BMPR1B, and GDF9) and FSH receptor (FSHR). Lambs neonatally exposed to DES or BPA showed an impaired ovarian response to oFSH with a lower number of follicles R2 mm in diameter together with a lower number of atretic follicles and no increase in E 2 serum levels in response to oFSH treatment. In addition, AR induction by oFSH was disrupted in granulosa and theca cells of lambs exposed to DES or BPA. An increase in GDF9 mRNA expression levels was observed in oFSH-primed lambs previously treated with DES or BPA50. In contrast, a decrease in BMPR1B was observed in BPA0.5-postnatally exposed lambs. The modifications in AR, GDF9, and BMPR1B may be associated with the altered ovarian function due to neonatal xenoestrogen exposure in response to an exogenous gonadotropin stimulus. These alterations may be the pathophysiological basis of subfertility syndrome in adulthood.Reproduction (2015) 149 645-655

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Section: Discussionmentioning

confidence: 53%

Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs

Rivera¹,

Varayoud²,

Rodríguez³

et al. 2015

Reproduction

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“…Several research groups have looked for possible associations between endogenous (natural luteal phase) or exogenous progesterone priming (treatment used to control the ovarian follicular dynamics) and the response to superovulation as a potential explanation for some of the persistent variability in superovulation seen between animals (Kanitz et al, 2002;Mapletoft et al, 2002). In this study, the aim was to investigate any differences in quantity and quality of embryos produced in response to either DIB or Cronipres progesterone ID combined with eCG for ovarian superstimulation in llamas.…”

Section: Short Communication Open Accessmentioning

confidence: 99%

Short Communication. Embryo yield in llamas synchronized with two different intravaginal progesterone-releasing devices and superovulated with eCG

Aller¹,

Abalos²,

Acuña³

et al. 2015

Span. j. agric. res.

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The objectives of this study were to compare the effects of two intravaginal devices (ID) containing the same dose (0.5 g) of progesterone (P 4 ) on subsequent ovarian response, embryo production and circulating P 4 concentration profile in llamas (Lama glama) treated with equine chorionic gonadotropin (eCG) for ovarian superstimulation. Female llamas were randomly assigned (n = 10 llamas per group) to one of the following groups and treated (Day 0) with an ID containing 0.5 g of vegetal P 4 to synchronize the emergence of a new follicular wave: i) DIB 0.5 ® and ii) Cronipres M15 ® . On Day 3 llamas were intramuscularly treated with 1000 IU of eCG. The IDs were removed on Day 7. Llamas were naturally mated (Day 9) and treated with GnRH analogue to induce ovulation. A second mating was allowed 24 h later. Embryos were collected between 7 and 8 days after the first mating. Blood samples were taken every day from Day 0 to Day 7 to measure circulating P 4 concentrations. The results indicated that DIB device maintained greater plasma P 4 levels as compared to Cronipres until Day 2. However, the mean (± SD) number of corpora lutea and recovered embryos was not affected (p < 0.05) by the type of ID (5.3 ± 2.6 vs 4.2 ± 2.2 and 3.5 ± 2.7 vs 2.6 ± 3.0 for DIB and Cronipres, respectively). In conclusion, both DIB and Cronipres devices can be successfully used to synchronize the emergence of follicular wave prior to a single dose of eCG in superovulation protocol in llamas.Additional key words: South American camelids; superovulation; hormonal treatment; embryo.

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“…The standard protocol that relies on superovulation after estrus detection still has some limitations, such as the need for heat detection, the need to start the superovulatory treatment at a specific time of the estrous cycle, the inability to schedule several collections on the same day, the inconsistency of results, and the fact that 20 to 30% of donors do not respond to the superovulatory treatment . This variability in superovulatory response remains one of the toughest challenges in ET programs in cattle (Mapletoft et al, 2002;Barros, 2004;Baruselli et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Effect of follicular wave synchronization on superovulatory response of Girolando embryo donors

Ferreira

Mello

Alves³

et al. 2014

R. Bras. Zootec.

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-The objective of this study was to evaluate the effect of the follicular wave synchronization method on the superovulatory response of Girolando embryo donors. Seven cows and five heifers were divided into three treatments according to the method of the follicular wave synchronization prior to superovulation. The donors were superovulated with eight FSH decreasing doses, adding 133 mg per animal. The superovulatory response was evaluated using an ultrasound device to quantify the number of corpora lutea. The number and quality of recovered structures were also evaluated. Animal category (cow or heifer) and genetic group influenced the superovulatory response, in which heifers showed a greater response (100% in all treatments) compared with cows, which showed 85.7%, 57.1% and 57.1% superovulatory response for standing estrus, GnRH and P4 + BE groups, respectively. The genetic group also showed influence on superovulatory response, in which the 3/8 animals had an average of 10.3 corpora lutea per donor compared with the 3/4 animals, which showed 4.9. The follicular wave synchronization treatments did not show differences in superovulatory response, recovered structures and viable structures. The treatment of follicular wave synchronization with GnRH or with P4 + BE can be used in Girolando donors with the same efficiency as the standing estrus group, and 3/8 Girolando heifers respond better to the superovulatory treatment.

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Recent advances in the superovulation in cattle

Cited by 202 publications

References 40 publications

Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs

Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs

Short Communication. Embryo yield in llamas synchronized with two different intravaginal progesterone-releasing devices and superovulated with eCG

Effect of follicular wave synchronization on superovulatory response of Girolando embryo donors

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