Recent Advances in the Synthesis of Diarylheptanoids

Sudarshan, Kasireddy; Yarlagadda, Suresh; Sengupta, Sagnik

doi:10.1002/asia.202400380

Chemistry An Asian Journal

2024

DOI: 10.1002/asia.202400380

|View full text |Cite

Recent Advances in the Synthesis of Diarylheptanoids

Kasireddy Sudarshan,

Suresh Yarlagadda,

Sagnik Sengupta

Abstract: In the quest for synthesizing biologically important natural products, medicinal chemists embark on an endless journey. This review focuses on the reports published towards the syntheses of diarylheptanoids, classifying them into linear, tetrahydropyran, diarylether, and biphenyl categories. The synthesis methods for each class from 2013 to 2023 are discussed, providing a comprehensive overview of the advancements in the field. Representative natural product examples are highlighted for each category. The revi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 9 publications

References 184 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Solvent role in molecular structure level (TD-DFT), topology, and molecular docking studies on liquid 2′, 4′-dichloroacetophenone

Mallika,

Revathi,

Balachandran

et al. 2024

Journal of King Saud University - Science

View full text Add to dashboard Cite

Solvent role in molecular structure level (TD-DFT), topology, and molecular docking studies on liquid 2′, 4′-dichloroacetophenone

Mallika,

Revathi,

Balachandran

et al. 2024

Journal of King Saud University - Science

View full text Add to dashboard Cite

Application of Metal–Organic Frameworks in Multicomponent Reactions

Teimouri,

Latifi,

Behraveshfar

2024

SynOpen

View full text Add to dashboard Cite

Metal-catalyzed multicomponent reactions are versatile synthetic protocols often used to prepare a range of different products. These reactions provide complete molecular diversity and high atom efficiency while saving energy. Recently, metal–organic frameworks have attracted attention as environmentally friendly catalytic systems as they possess an abundance of catalytic sites in ordered crystal skeletons. In this graphical review, we highlight the recent progress made utilizing metal–organic frameworks to facilitate multicomponent reactions.

show abstract

Aspidosperma nitidum reduces parasite load and modulates cytokines in BALB/c mice infected with Leishmania (Leishmania) amazonensis

Brígido,

Varela,

Quadros Gomes

et al. 2024

Front. Chem.

View full text Add to dashboard Cite

The lack of vaccines shows the need for alternative leishmaniasis treatments. In vitro study previously demonstrated the leishmanicidal activity of A. nitidum extracts. This study describes for the first time, the antileishmanial activity of A. nitidum extracts in infected Balb/c mice and its immunomodulatory effect. The extract (EE) was obtained by maceration of the peel powder with ethanol, which was fractionated by acid-base partition, originating the alkaloid (FA) and neutral (FN) fractions. EE and FA were analyzed using mass spectroscopy. Daily intragastric treatment was performed with EE and FA, at doses of 200 mg/kg and 400 mg/kg, in Balb/c mice with 28 days of infection by Leishmania amazonensis. A thickness gauge was used to assess the progression of the lesion and the MTT method to determine the parasite load in the spleen. The quantification of IL-10 and IFN-γ was performed by ELISA. Analysis of the mass spectrum of EE indicated the presence of the alkaloids corynantheol and yohimbine, while in FA the alkaloid dihydrocorynantheol was identified. To elucidate the mode of interaction of these alkaloids with the TR protein, molecular target of antileishmanial drugs, we used molecular modeling approaches such as docking, molecular dynamics simulations and free energy affinity. Treatment with EE for 28 days at the highest dose tested, significantly reduced the size of the lesion. EE and FA after 28 days of treatment showed dose-dependent antileishmanial activity, which reduced the parasite load in the spleen of infected mice by 42.5% and 22.1%, respectively. Both EE and FA presented immunomodulatory effect, as they decreased IL-10 expression and increased IFN-y levels. The effectiveness of A. nitidum in the treatment of cutaneous leishmaniasis was proven in this study. The results obtained in silico demonstrated that the compounds are capable of interacting with the catalytic residues of the TR. The affinity energy results demonstrated that the complexes formed are favorable for enzymatic inhibition. The alkaloids present in the plant have demonstrated not only antileishmanial activity, but also the ability to modulate the host’s immune response. These promising results open perspectives for developing more effective and comprehensive treatments against cutaneous leishmaniasis.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Recent Advances in the Synthesis of Diarylheptanoids

Cited by 9 publications

References 184 publications

Solvent role in molecular structure level (TD-DFT), topology, and molecular docking studies on liquid 2′, 4′-dichloroacetophenone

Solvent role in molecular structure level (TD-DFT), topology, and molecular docking studies on liquid 2′, 4′-dichloroacetophenone

Application of Metal–Organic Frameworks in Multicomponent Reactions

Aspidosperma nitidum reduces parasite load and modulates cytokines in BALB/c mice infected with Leishmania (Leishmania) amazonensis

Contact Info

Product

Resources

About