Recent advances in the synthesis of piperazine based ligands and metal complexes and their applications

Abstract

The piperazine ring is an indispensable part of many biomolecules and can be easily modified through substitution on the ring nitrogen for desired application in pharmacology as well as metal binding studies.

Oxidative DNA cleavage mediated by a new unexpected [Pd(BAPP)][PdCl4] complex (BAPP = 1,4-bis(3-aminopropyl)piperazine): crystal structure, DNA binding and cytotoxic behavior

“…17 Additionally, a wide range of medicinal applications of compounds bearing piperazine scaffold such as cardioprotective, antidiabetic, relieving pain agent, antituberculosis and antimalarial activities. 18,19 In addition, generally the presence of a pair of cis-primary amines situated in the precursor ligand is the primary requirement for successful synthesis of the complex. Thus, structural studies and the evaluation of the antimicrobial activity of copper(II), cobalt(II) and nickel(II) metal complexes of a hexadentate ligand 1,4-bis((2-hydroxybenzaldehyde)propyl)piperazine were also reported.…”

Investigation of the influence of chirality and halogen atoms on the anticancer activity of enantiopure palladium(ii) complexes derived from chiral amino-alcohol Schiff bases and 2-picolylamine

“…Indeed, ligands such as 1,10-phenanthroline, 2,2-bipyridyl, imidazole, piperazine and pyridine have provided metal complexes with remarkable anticancer activity and negligible cytotoxicity profile. 15…”

Reducing the reprocessing and healing temperature of polyurea with piperazine-based hindered urea bonds

“…Piperazine is a common diamine with a typical secondary aliphatic amine. 36 It has higher nucleophilic reaction activity than the primary amine, which makes it easier to react with isocyanate and the produced urea is thus more stable. At the same time, the amino groups of piperazine are located on the six-membered ring, 37 which bear a high steric hindrance.…”