Recent advances in the synthesis, X-ray diffraction characterization and application of cadmium complexes with hydrazine based bis-pyridine Schiff base ligands

Halder, Biplab; Middya, Puspendu; Chattopadhyay, Shouvik

doi:10.1016/j.molstruc.2023.137416

Journal of Molecular Structure

2024

DOI: 10.1016/j.molstruc.2023.137416

|View full text |Cite

Recent advances in the synthesis, X-ray diffraction characterization and application of cadmium complexes with hydrazine based bis-pyridine Schiff base ligands

Biplab Halder,

Puspendu Middya,

Shouvik Chattopadhyay

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 151 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Syntheses, crystal structures and fluorescence properties of zinc(II) and cadmium(II) complexes based on 2-phenoxyaniline Schiff base

Cao,

Jia,

Chen

et al. 2024

Transit Met Chem

View full text Add to dashboard Cite

Syntheses, crystal structures and fluorescence properties of zinc(II) and cadmium(II) complexes based on 2-phenoxyaniline Schiff base

Cao,

Jia,

Chen

et al. 2024

Transit Met Chem

View full text Add to dashboard Cite

Synthesis, crystal structures and antiproliferative activities of a new indole-containing dipyridylmethanone hydrazone Schiff base and its cadmium(II) complex

Zhang,

Wang,

Xing

et al. 2024

Acta Crystallogr C Struct Chem

View full text Add to dashboard Cite

In this study, we introduce a novel indole-containing pyridine-based Schiff base, (E)-2-({[bis(pyridin-2-yl)methylidene]hydrazin-1-ylidene}methyl)-1H-indole, C20H15N5 (2-DPHI), and its cadmium(II) complex poly[[2-({[bis(pyridin-2-yl)methylidene]hydrazin-1-ylidene}methyl)-1H-indole]di-μ-chlorido-cadmium(II)], [CdCl2(C20H15N5)] n (pCd2), as potential anticancer agents. The Schiff base was synthesized by reacting dipyridylmethanone hydrazone with indole-2-formaldehyde, while the cadmium complex was prepared by combining CdCl2 and 2-DPHI in methanol at room temperature. Both compounds were evaluated for their cytotoxicity against three human cancer cell lines (A375, A549 and HeLa) and a normal cell line (HFF-1). The ligand 2-DPHI exhibited notable antitumour activity, with an IC50 value of 12.22 µM against A375 and 15.17 µM against A549 after 48 h, while the pCd2 complex showed an even stronger inhibition of A375 cells, with an IC50 value of 4.88 µM, outperforming both 2-DPHI and CdCl2. Both compounds demonstrated lower toxicity towards normal cells compared to cancer cells. The structures of 2-DPHI and pCd2 were fully characterized using single-crystal X-ray diffraction, elemental analysis, high-resolution mass spectrometry and FT–IR, 1H NMR, 13C NMR and UV–Vis spectroscopy.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Recent advances in the synthesis, X-ray diffraction characterization and application of cadmium complexes with hydrazine based bis-pyridine Schiff base ligands

Cited by 2 publications

References 151 publications

Syntheses, crystal structures and fluorescence properties of zinc(II) and cadmium(II) complexes based on 2-phenoxyaniline Schiff base

Syntheses, crystal structures and fluorescence properties of zinc(II) and cadmium(II) complexes based on 2-phenoxyaniline Schiff base

Synthesis, crystal structures and antiproliferative activities of a new indole-containing dipyridylmethanone hydrazone Schiff base and its cadmium(II) complex

Contact Info

Product

Resources

About