2022
DOI: 10.1039/d2qo00278g
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Recent advances in the transition metal-free synthesis of heterocycles from α,β-unsaturated ketones

Abstract: Heterocyclic compounds are an inevitable part of our life. These important classes of molecules have a wide range of applications starting from life-sustaining drugs to agrochemicals. Numerous methods, including metal...

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Cited by 20 publications
(5 citation statements)
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“…In recent times, base and catalyst-free Michael addition reactions were more significant, offering environmental advantages, and have also embraced a continued interest for chemists in the construction of CÀ C bonds. [81] Michael addition reactions without any catalysts and bases in the presence of a solvent or without any solvent have been regarded as an environmentally friendly synthetic approach. [82] Various biologically important compounds are synthesized by Michael/ hetero-Michael addition reaction.…”
Section: Michael Addition Reactions Under Catalyst-free and Base-free...mentioning
confidence: 99%
“…In recent times, base and catalyst-free Michael addition reactions were more significant, offering environmental advantages, and have also embraced a continued interest for chemists in the construction of CÀ C bonds. [81] Michael addition reactions without any catalysts and bases in the presence of a solvent or without any solvent have been regarded as an environmentally friendly synthetic approach. [82] Various biologically important compounds are synthesized by Michael/ hetero-Michael addition reaction.…”
Section: Michael Addition Reactions Under Catalyst-free and Base-free...mentioning
confidence: 99%
“…1 In order to obtain them quickly and easily, synthetic chemists have designed various versatile organic synthons and developed a series of efficient methods. 2 Among the designed synthons, straight-chain ω-amino-α,β-unsaturated carbonyl compounds bearing both a nitrogen-centered nucleophile and a Michael acceptor could undergo intra- and intermolecular aza-Michael addition reactions for the synthesis of a C–N bond in nitrogen-containing heterocycles. The length of the carbon chain can be adjusted to generate five- or six-membered nitrogen-containing heterocycles.…”
Section: Introductionmentioning
confidence: 99%
“…In particular, small molecule synthesis and complex scaffold synthesis can be efficiently realized from easily available starting materials under mild reaction conditions. 1…”
Section: Introductionmentioning
confidence: 99%