Recent advances in the use of enzyme-catalysed reactions in organic synthesis

Turner, N. J.

doi:10.1039/np9941100001

Cited by 32 publications

(5 citation statements)

References 101 publications

(62 reference statements)

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“…However, the configuration of the stereocenter at C-4 in some cases depends on the structure of the acceptor (particularly for TagA). [34][35][36] 2.1.1.1. Fructose 1,6-Biphosphate (FBP) Aldolase (FruA).…”

Section: Enzymatic Aldol Reactionsmentioning

confidence: 99%

“…293 Starting out from the structure of a potent inhibitor of influenza sialidase (32), the enzyme NeuA has been evolved, using structure-guided saturation mutagenesis, to increase its activity toward aldehyde substrates of general structure (33). One variant, Glu192Asn, showed a 49fold improvement in catalytic efficiency toward the target analogue and also had broad scope, which was exploited in the parallel synthesis of a small library of sialic acid analogues of general structure (34). 312 Related compounds, such as 35, are potent and selective inhibitors of influenza A sialidase.…”

Section: Synthetic Applicationsmentioning

confidence: 99%

“…These enzymes have a broad substrate (acceptor aldehyde) specificity and high level of stereocontrol at C-3. However, the configuration of the stereocenter at C-4 in some cases depends on the structure of the acceptor (particularly for TagA). − …”

Section: Enzymatic Aldol Reactionsmentioning

confidence: 99%

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C−C Bond-Forming Lyases in Organic Synthesis

et al. 2011

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Section: Enzymatic Aldol Reactionsmentioning

confidence: 99%

Section: Synthetic Applicationsmentioning

confidence: 99%

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C−C Bond-Forming Lyases in Organic Synthesis

et al. 2011

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“…Esters are naturally prevalent and their preparation and hydrolysis are subject to asymmetric catalysis by a variety of esterases and lipases. Several enzymes are widely used as biocatalysts for the resolution of racemic alcohols and esters by selective esterification and hydrolysis, respectively, − collectively the most industrially applicable biotransformations.…”

Section: Enzyme-catalyzed Transesterification Allows the Classical Ki...mentioning

confidence: 99%

Cyanohydrins in Nature and the Laboratory: Biology, Preparations, and Synthetic Applications

1999

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K., in 1994 with his B.A. degree in Natural Sciences (Chemistry), which included a molecular modeling project with Dr. Jonathan Goodman. He was awarded his Ph.D. degree in 1998 for a thesis on Biocatalytic Preparation and Chemistry of Some Novel Cyanohydrin Systems, under the supervision of Professor Stan Roberts at the Universities of Exeter and Liverpool, U.K. A subsequent Brax Limited Research Fellowship at the University of Liverpool involved the design and synthesis of mass markers as part of a project to investigate the potential of mass spectrometry in genomics and proteomics. He is currently working in the intellectual property area.

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“…3.1.1) catalyze the hydrolysis of esters to the corresponding alcohol and carboxylic acid. They are of increasing importance for applications in biocatalysis (Turner, 1994;Azerad, 1995) due to the diverse range of properties concerning substrate specificity, regioselectivity and enantioselectivity available from various members of this class of enzymes.…”

Section: Introductionmentioning

confidence: 99%