Recent advances in the use of tandem reactions for organic synthesis

High-Throughput Screening of Heterogeneous Catalysts for the Conversion of Furfural to Bio-Based Fuel Components

“…The aim of this research is to identify the most promising family of metal catalysts and reaction conditions for the one-step production of 2-methoxymethylfuran (furfuryl methylether, FME) from furfural, thereby avoiding the synthetic efficiency loss that generally occurs in multistep processes [23]. A high-throughput program screening 35 commercial catalysts at three temperatures and a fixed reaction time, using GC for analysis was conducted.…”

Three‐component 1,3‐dipolar cycloaddition reactions in synthesis of spiro[pyrrolidine‐2,3′‐oxindoline] derivatives

“…Also, spiro oxindoles have been reported to behave as aldose reductase [2], poliovirus, and rhinovirus 3C-proteinase inhibitors [4]. Sequential transformations enable the facile syntheses of complex target molecules from simple building blocks in a single preparative step [5]. Their value is amplified if they also create multiple stereogenic centers [6].…”

Rhodium‐Catalyzed Bis‐Hydroaminomethylation of Linear Aliphatic Alkenes with Piperazine

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Their inherent advantage of reducing both waste and timei sv ery attractive for academic researchers as wella si ndustrial applications.H ence, more and more generalc onceptsf or the mergero f two or more catalytic steps without the need for intermittent work-up of the intermediates have been developed. Of particular usefulness are tandem catalytic systems that allow for the selective synthesis of target molecules,w hich wouldn ot be accessible by am ultistep approach, because the respective intermediate is not or only impracticably isolable.B esidest he development of new methodologies for the combination of reactions teps,i ncluding necessary strategies to address catalyst incompatibilitiesa nd time resolved transformations, [17,18] the extensiono fe xisting tandem catalytic systems for example,f or the conversion of renewable resources, has also great potential.…”