Recent Advances in Thermoplastic Microfluidic Bonding

Giri, Kiran; Tsao, Chia Wen

doi:10.3390/mi13030486

Cited by 42 publications

(29 citation statements)

References 157 publications

(259 reference statements)

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“…Moreover, they have various physicochemical properties for different microfluidic applications, such as suitable mechanical rigidity, acid or base resistivity, organic solvent resistivity, and low water absorbance. 114 Thermoplastics, such as polystyrene (PS), polycarbonate, poly(methyl methacrylate) (PMMA), and cyclic olefin copolymer, have been generally used in the biomimetic membrane engineering. The techniques for the preparation of thermoplastic membranes include phase inversion and separation, injection molding, and electrospinning.…”

Section: Wettability and Hydrophilicitymentioning

confidence: 99%

“…The techniques for the preparation of thermoplastic membranes include phase inversion and separation, injection molding, and electrospinning. 114,115 Although PDMS has been widely used in the construction of microfluidic devices, it can adversely affect the final device. The absorption of small hydrophobic molecules by PDMS can cause a reduction in the hydrophilic/hydrophobic ratio.…”

Section: Wettability and Hydrophilicitymentioning

confidence: 99%

See 1 more Smart Citation

Engineered Biomimetic Membranes for Organ-on-a-Chip

Rahimnejad

Rasouli

Jahangiri

et al. 2022

ACS Biomater. Sci. Eng.

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Organ-on-a-chip (OOC) systems are engineered nanobiosystems to mimic the physiochemical environment of a specific organ in the body. Among various components of OOC systems, biomimetic membranes have been regarded as one of the most important key components to develop controllable biomimetic bioanalysis systems. Here, we review the preparation and characterization of biomimetic membranes in comparison with the features of the extracellular matrix. After that, we review and discuss the latest applications of engineered biomimetic membranes to fabricate various organs on a chip, such as liver, kidney, intestine, lung, skin, heart, vasculature and blood vessels, brain, and multiorgans with perspectives for further biomedical applications.

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Section: Wettability and Hydrophilicitymentioning

confidence: 99%

Section: Wettability and Hydrophilicitymentioning

confidence: 99%

Engineered Biomimetic Membranes for Organ-on-a-Chip

Rahimnejad

Rasouli

Jahangiri

et al. 2022

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…As for the non-mold-based techniques, CNC micromachining, laser micromachining, and 3D printing were reviewed. For the packaging or bonding of polymer microfluidic chips, several great reviews can be found in the literature [ 28 , 29 ]. Although cellulose-based filter paper is composed of polymers and could be counted as a polymeric material, paper-based microfluidics was not included in this review.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Polymer Microfluidics: An Overview

Juang

Chiu

2022

Polymers

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Microfluidic platform technology has presented a new strategy to detect and analyze analytes and biological entities thanks to its reduced dimensions, which results in lower reagent consumption, fast reaction, multiplex, simplified procedure, and high portability. In addition, various forces, such as hydrodynamic force, electrokinetic force, and acoustic force, become available to manipulate particles to be focused and aligned, sorted, trapped, patterned, etc. To fabricate microfluidic chips, silicon was the first to be used as a substrate material because its processing is highly correlated to semiconductor fabrication techniques. Nevertheless, other materials, such as glass, polymers, ceramics, and metals, were also adopted during the emergence of microfluidics. Among numerous applications of microfluidics, where repeated short-time monitoring and one-time usage at an affordable price is required, polymer microfluidics has stood out to fulfill demand by making good use of its variety in material properties and processing techniques. In this paper, the primary fabrication techniques for polymer microfluidics were reviewed and classified into two categories, e.g., mold-based and non-mold-based approaches. For the mold-based approaches, micro-embossing, micro-injection molding, and casting were discussed. As for the non-mold-based approaches, CNC micromachining, laser micromachining, and 3D printing were discussed. This review provides researchers and the general audience with an overview of the fabrication techniques of polymer microfluidic devices, which could serve as a reference when one embarks on studies in this field and deals with polymer microfluidics.

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“…The challenges associated with solubility and viscosity necessitate the use of solvents and/or temperatures that are incompatible with common microfluidic materials and mixer designs. For example, microfluidic modules fabricated from soft materials (e.g., poly(dimethylsiloxane) (PDMS), poly(methyl methacrylate) (PMMA)) lack requisite chemical resistance to function adequately with many organic solvents and/or thermal stability needed for operation at high temperatures . Glass and silicon microfluidic modules either incorporate a sealing adhesive that may also suffer from the aforementioned chemical and/or thermal stability issues or alternatively require some complex etching and bonding process. , As a result, alternative approaches are required since elevated temperature operability is necessary to achieve dissolution or low viscosity.…”

Section: Introductionmentioning

confidence: 99%

Composition Gradient High-Throughput Polymer Libraries Enabled by Passive Mixing and Elevated Temperature Operability

et al. 2022

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The development of high-throughput experimentation (HTE) methods to efficiently screen multiparameter spaces is key to accelerating the discovery of high-performance multicomponent materials (e.g., polymer blends, colloids, etc.) for sensors, separations, energy, coatings, and other thin-film applications relevant to society. Although the generation and characterization of gradient thin-film library samples is a common approach to enable materials HTE, the ability to study many systems is impeded by the need to overcome unfavorable solubilities and viscosities among other processing challenges under ambient conditions. In this protocol, a solution coating system capable of operating temperatures over 110 °C is designed and demonstrated for the deposition of composition gradient polymer libraries. The system is equipped with a custom, solvent-resistant passive mixer module suitable for high-temperature mixing of polymer solutions at ambient pressure. Residence time distribution modeling was employed to predict the coating conditions necessary to generate composition gradient films using a poly(3-hexylthiophene) and poly(styrene) model system. Poly(propylene) and poly(styrene) blends were selected as a first demonstration of high temperature gradient film coating: the blend represents a polymer system where gradient films are traditionally difficult to generate via existing coating approaches due to solubility constraints under ambient conditions. The methodology developed here is expected to widen the range of solution processed materials that can be explored via high-throughput laboratory sampling and provides an avenue for efficiently screening multiparameter materials spaces and/or populating the large data sets required to enable data-driven materials science.

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Recent Advances in Thermoplastic Microfluidic Bonding

Cited by 42 publications

References 157 publications

Engineered Biomimetic Membranes for Organ-on-a-Chip

Engineered Biomimetic Membranes for Organ-on-a-Chip

Fabrication of Polymer Microfluidics: An Overview

Composition Gradient High-Throughput Polymer Libraries Enabled by Passive Mixing and Elevated Temperature Operability

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