Recent advances in transamidation of unactivated amides

Abstract

In recent years, transamidation has been an essential topic in the formation of amide bonds over the conventional route due to chemoselectivity and greenside products. So many groups have disclosed new amide transformation techniques. Transamidation is typically classified into two categories based on amide activation: activated amide and unactivated amide. We conducted a review of the pertinent literature that discusses the cross amidation reactions of unactivated amides employing a variety of reagents, enabling contemporary research professionals to overcome synthetic barriers. Graphical abstract

Pd NPs decorated on crosslinked sodium alginate modified iron-based metal–organic framework Fe(BTC) as a green multifunctional catalyst for the oxidative amidation

“…1,2 Traditional methods for synthesizing amides have several drawbacks, including the use of toxic reagents, precious metal catalysts, long reaction times, and acyl halide sources. 3,4 Therefore, the development of atom-efficient methods is essential for achieving more sustainable and environmentally friendly chemical processes. One promising alternative for amide synthesis is the use of alcohols.…”

“…Alcohols can be converted to amides through a tandem oxidation process under oxidative conditions, either in situ via carboxylic acids or aldehydes. 4,5 These oxidative amidation reactions from alcohols provide attractive pathways to reduce the consumption of organic compounds, synthetic costs, and the need for complex synthetic methods. 6 While alternative methods have been explored, oxidative amidations have gained signicant attention due to their simplicity, cost-effectiveness, and reliance on easily accessible starting materials.…”