Recent advances in transition-metal-free trifluoromethylation with Togni's reagents

Abstract

Developments in transition-metal-free trifluoromethylation have attracted broad interests driven by the increasing importance of CF3-containing compounds. Among diverse trifluoromethylation reagents, Togni’s reagents displayed exceptional reactivities, and abundant meaningful organic transformations...

Switchable aroylation and diaroylation of allyl sulfones with aldehydes enabled by decatungstate photocatalysis

“…The great tolerance to halogens provided the potential application of these compounds in further functionalization by cross-coupling reactions. 21 Benzaldehyde with an electron-donating group (–CH 3 ) on the benzene ring led to the formation of 4n in a relatively poor yield (38%). In contrast, benzaldehyde with a sensitive –OH group reacted smoothly to afford 4o in a good yield (73%).…”

A straightforward access to trifluoromethylated natural products through late-stage functionalization

“…Although several reviews have summarized recent developments in the trifluoromethylation of various molecules, they have focused mainly on certain catalytic modes, 32 functional groups, 33 or applications of specific CF 3 reagents, 34 and a general review on the direct trifluoromethylation of NPs is absent. A timely review is in high demand because considerable progresses have been achieved in this field during the past decade.…”

Visible-Light-Initiated Sequential Trifluoromethylation/Remote C(sp3)–H Alkynylation of Vinyl Azides by Radical Relay

“…Over the past few decades, a myriad of practical methods have been reported in this field. 2,3 Among the established synthetic approaches, trifluoromethylative difunctionalization of carbon− carbon multiple bonds is a powerful method which assembles structurally complex CF 3 -containing compounds with the concomitant installation of an additional functionality. 3 On the other hand, alkynes as versatile structural motifs provide direct accesses to many other functionalities.…”