Recent advances in treatment Crimean–Congo hemorrhagic fever virus: A concise overview

Gholizadeh, Omid; Jafari, Mohammad Mahdi; Zoobinparan, Rezvane; Yasamineh, Saman; Tabatabaie, Raheleh; Akbarzadeh, Sama; Amini, Parya; Eslami, Majid; Yousefi, Bahman; Dadashpour, Mehdi

doi:10.1016/j.micpath.2022.105657

Cited by 16 publications

(9 citation statements)

References 71 publications

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“…HDT-321 is for Crimean-Congo hemorrhagic fever virus (CCHFV). CCHFV is found and spread by ticks that feed on a variety of domestic and wild animals (Gholizadeh et al 2022). People can be infected directly by ticks or through contact with products from infected animals.…”

Section: Vaccine Pipelinementioning

confidence: 99%

The Race to Manufacture COVID-19 Vaccines: Emerging Vaccine Technologies

2023

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Detailing how Australia’s Therapeutics Goods Administration conducted horizon scanning for new vaccines during the pandemic to assist ADB, this report is designed to help countries in Asia and the Pacific prepare for future outbreaks. It provides details of 16 vaccine manufacturers with novel and established vaccine technologies adapted to new pathogens like SARS-CoV-2, the virus that causes COVID-19. Offering information on their vaccine pipeline and partnerships, the report shows their approach to working with ADB’s developing member countries and can be used to inform decisions related to vaccine manufacturing and procurement.

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Section: Vaccine Pipelinementioning

confidence: 99%

The Race to Manufacture COVID-19 Vaccines: Emerging Vaccine Technologies

2023

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“…MiRNAs are short, single-stranded RNA molecules that play a crucial role in controlling cellular processes such as development, proliferation, and neoplastic transformation [9,10]. Their potential as biomarkers and drug targets is highlighted by their correlation with the progression of the disease [11][12][13]. A growing body of evidence indicates that miRNA-based therapies, which involve the regulation of miRNA expression, may hold great potential [14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Journal of Pharmaceutical Sciences and Drug Manufacturing 1 (2024)[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] …”

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In silico analysis revealed the prognostic potential of a miRNA panel in lung carcinoma

Mohanad,

Fakhr Eldeen,

Shamloula

2024

Journal of Pharmaceutical Sciences and Drug Manufacturing

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Background. This research aims to identify potential prognostic biomarkers for squamous cell lung carcinoma (LUSC) by implementing bioinformatics tools to unveil the relationship between microRNAs (miRNAs) and LUSC, specifically by identifying the miRNAs and their critical target genes.Methods. We employed the Cancer Genome Atlas (TCGA)-LUSC dataset to identify differentially expressed miRNAs (DEmiRs) and genes (DEGs) utilizing R software. Subsequently, a lasso Cox regression survival model was developed to predict key prognostic DEmiRs. Their target genes were predicted using miRDB repository. Venn diagram was employed to identify the consensus genes shared between these target genes and DEGs in the TCGA-LUSC dataset. ClusetrProfiler analyzed Gene Ontology (GO) and KEGG pathways to comprehend these genes' biological functions. The STRING database and Cytoscape applications constructed the consensus gene proteinprotein interactions network.Results. Lasso model predicted 6 prognostic DEmiRs (hsa-miR1270, hsa-miR-1291, hsa-19b-2, hsa-miR-2277, hsa-miR-4791, hsa-miR-485) for LUSC with 96.67% sensitivity and 68.54% specificity. Venn diagram retrieved 906 consensus genes shared between DEGs and these 6 prognostic DEmiRs. These genes were mainly related to protein-binding, neuroactive ligand receptor interaction, retinoid metabolism, carcinogenesis, cell cycle, and system development. Network analysis in Cytoscape STRING applications identified 19 crucial genes (SDC4,

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“…In high-risk exposures, treatment is done via the use of ribavirin ( 16 ). However, there is controversy over the effectiveness of ribavirin as a treatment of CCHF ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Distribution pattern of Crimean–Congo Hemorrhagic Fever in Asia and the Middle East

Aslam

Abbas

Alsayeqh

2023

Front. Public Health

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Crimean–Congo Hemorrhagic Fever (CCHF) is one of the most important vector-borne diseases of zoonotic potential that can be acquired following the bite of the Hyalomma species of ticks. It is a highly prevalent disease in Asia and the Middle East. The risk factors of this disease are contact with infected tissue, blood, patient, or livestock in the acute viremic phase, infected tick bites, or the manual removal of ticks. The disease is clinically described as progressive hemorrhages, fever, and pain in musculature. Biochemical tests reveal elevated levels of creatinine phosphokinase, alanine transaminase, aspartate aminotransferase, and lactate dehydrogenase. Clotting time is prolonged in pro-thrombin tests, and pathogenesis is mostly related to the disruption of the epithelium during viral replication and indirectly by secreting cytotoxic molecules. These molecules cause endothelial activation and result in the loss of function. Supportive therapy is given through blood or plasma infusions to treat or manage the patients. According to the most advanced studies, CCHF can be treated by Ribavirin, which is an antiviral drug that shows excellent results in preventing the disease. Health-care staff are more prone to infection. The hemorrhagic phase represents a high risk for accidental exposures. This literature review presents a comprehensive overview of the viral epidemiology, zoonotic perspectives, and significant risk factors of CCHF in various Middle East and Asian countries. Furthermore, the pathophysiology and preventive strategies of CCHF have also been discussed as well as legislation and policies regarding public outreach programs, research, and development aimed at infection prevention and control that are required at a global level.

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Recent advances in treatment Crimean–Congo hemorrhagic fever virus: A concise overview

Cited by 16 publications

References 71 publications

The Race to Manufacture COVID-19 Vaccines: Emerging Vaccine Technologies

The Race to Manufacture COVID-19 Vaccines: Emerging Vaccine Technologies

In silico analysis revealed the prognostic potential of a miRNA panel in lung carcinoma

Distribution pattern of Crimean–Congo Hemorrhagic Fever in Asia and the Middle East

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