Recent Advances in Trigeminal Neuralgia and Its Management: A Narrative Review

Burman, Sourav; Khandelwal, Ankur; Chaturvedi, Arvind

doi:10.1055/s-0041-1726152

Cited by 2 publications

(4 citation statements)

References 39 publications

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“…The drug is now licensed as an additional therapy for focal seizures since it targets voltage-gated sodium channels. For treating pain in TN, emerging drugs for instance eslicarbazepine and vixotrigine are being assessed [38].…”

Section: Potential Therapy For Trigeminal Neuralgiamentioning

confidence: 99%

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Recent update on trigeminal neuralgia

Islam

Park

2022

J Korean Ster Func Neurosurg

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Trigeminal neuralgia (TN), a long-term disorder affecting the trigeminal nerve, is a form of debilitating neuropathic pain. Although the underlying pathogenesis of TN is debatable, loss of myelin along the trigeminal nerve due to direct compression from a blood vessel or secondary to other conditions such as multiple sclerosis or stroke is thought to be the principal cause. Paroxysmal sporadic pain, with unilateral onset, is the main phenomenon of TN. TN is typically diagnosed clinically. Medications, surgery, and complementary techniques are among the current therapy options for altering the neural circuits associated with TN. Nevertheless, anti-epileptic and tricyclic antidepressant medications are recognized as first-line treatments, and surgical treatment may be required for patients who have not obtained a therapeutic effect with at least three medications, have experienced intolerable side effects, or have symptoms that are not resolving. Stimulation of brain regions is an emerging off-label technique that has the potential to offer pain relief from TN, but sufficient data and more extensive studies on both animals and humans are yet to be published. More specifically, convenient diagnostic techniques and affordable treatment modalities for TN have become crucial needs in order to reduce the psychological and socio-economical losses caused by TN.

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Section: Potential Therapy For Trigeminal Neuralgiamentioning

confidence: 99%

“…Misoprostol is a prostaglandin E1 analogue that has been shown to alleviate pain in TN patients with associated MS in case studies. Capsaicin, topical or intranasal lignocaine are among the several treatment options available, although their extensive use is not advised at this point [38].…”

Section: Potential Therapy For Trigeminal Neuralgiamentioning

confidence: 99%

Recent update on trigeminal neuralgia

Islam

Park

2022

J Korean Ster Func Neurosurg

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“…Signals coming from this excited neurons are transmitted to the somatosensory cortex and may be further interpreted as pain. [15,16] The bioresonance hypothesis states that the trigeminal nerve, which is submerged in cerebrospinal fluid (CSF), vibrates at its own specific frequency. When the structures surrounding the CNV vibrate at similar frequency, the resonance of the trigeminal nerve occurs.…”

Section: Etiology and Pathomechanismmentioning

confidence: 99%

“…[17] The ignition theory affirms that the damaged or injured afferent neurons of trigeminal root or trigeminal ganglion reveal itself as hyperexcitability of the axons which leads to synchronized discharge activity causing pain paroxysms. [16,18]…”

Section: Etiology and Pathomechanismmentioning

confidence: 99%

Trigeminal Neuralgia - where are we today?

Perszke

Egierska

Martynowicz

2022

J Educ Health Sport

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Introduction: Trigeminal neuralgia (TN) is one of the most crippling facial pain syndromes, which has a significant impact on quality of life. This chronic disorder presents as brief shock-like paroxysmal severe, stabbing pain with rapid onset in the distribution of trigeminal nerve (CNV). The aim of this article was to review the recent literature about the epidemiology, pathogenesis, diagnosis, treatment methods and the important advances in all these fields.Etiology and pathomechanism: The best known and tested theory on the genesis of the trigeminal neuralgia seems to be a nerve compression at the nerve root entry-zone. However there are other theories like the trigeminal convergence-projection theory, the bioresonance hypothesis or the ignition theory that are trying to explain the etiology of TN. Treatment: Available treatment methods consist mainly of medications and surgical procedures. Surgical treatment may be divided into 2 categories: destructive and non-destructive. Among these interventions we can distinguish percutaneous rhizotomy stereotactic radiosurgery and microvascular decompression. All of them are very efficacious, however MVD is approved as the gold standard in the treatment of TN. Botulinum neurotoxin type A injections are not the first line for treatment, but it may be an attractive alternative for classic pharmaceutical or surgical therapy, as it’s safe and effective. Acupuncture is also proposed in recent studies as a valuable treatment option, even though there is little well-designed research.Conclusion: Much remains to be learned about the diagnosis, pathomechanism and methods of treatment of neuropathic pain and the efficacy of each of them. Further evidence-based studies are needed, as the amount of reliable materials is still not sufficient and lots of them have yet to be examined.

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Recent Advances in Trigeminal Neuralgia and Its Management: A Narrative Review

Cited by 2 publications

References 39 publications

Recent update on trigeminal neuralgia

Recent update on trigeminal neuralgia

Trigeminal Neuralgia - where are we today?

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