Recent advances in tumor biomarker detection by lanthanide upconversion nanoparticles

Abstract

Early tumor diagnosis could reliably predict the behavior of tumors and significantly reduce their mortality. Due to the response to early cancerous changes at the molecular or cellular level, tumor...

Polydopamine-Coated Manganese-Doped Upconversion Nanoparticles as Potential UCL/MRI Dual-Mode Probes

“…3,4 Recently, lanthanide-doped upconversion luminescence nanoparticles, which convert near-infrared (NIR) radiation into visible or UV light, have been identified as next-generation probes for photoluminescence bioimaging. This is due to their superior tissue permeability, 5 photostability and thermal stability, 6,7 low toxicity, and resistance to photobleaching. 8 However, the utility of in vivo optical imaging is hampered by its relatively low spatial resolution, imaging depth, high autofluorescence, and poor tissue penetration.…”

“…Optical imaging, owing to its high precision, sensitivity, rapid response, operational flexibility, and simplicity, has emerged as an essential tool in oncology treatment, cancer research, and disease surveillance. , This technique enables the visualization of living organisms from cellular to animal scales via upconversion luminescence (UCL) imaging. , Recently, lanthanide-doped upconversion luminescence nanoparticles, which convert near-infrared (NIR) radiation into visible or UV light, have been identified as next-generation probes for photoluminescence bioimaging. This is due to their superior tissue permeability, photostability and thermal stability, , low toxicity, and resistance to photobleaching . However, the utility of in vivo optical imaging is hampered by its relatively low spatial resolution, imaging depth, high autofluorescence, and poor tissue penetration .…”